Search

This review reports on the knowledge about odourant-olfactory receptor interactions and their projection within the field of structure-odour relationships (SOR). We provide a list of agonists and odour spaces associated with deorphanized human olfactory receptors. The link between olfactory receptor responses, differential perception and subtleties within odour families is discussed. Copyright © 2015 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

ABSTRACT A joint approach that combines molecular modelling and fluorescence spectroscopy is used to study the affinity of an odorant binding protein towards various odorant molecules. We focus on the capability of molecular modelling to rank odorants according to their affinity with this protein, which is involved in the sense of smell. Although ligand-based approaches are unable to propose an accurate model attending to the strength of the bond with the odorant-binding protein, receptor-based structures considering either static or dynamic structure of the protein perform equally to discriminate between good, medium and low affinity odorants. Such approaches will be useful for further rational design of either odorants or bio-inspired sensors. Copyright © 2012 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]