1. The role of NADPH-oxidase in paracrine and autocrine regulation of platelet functional activity
- Author
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Talanov Sa, Patalakh, and Liashenko Ti
- Subjects
inorganic chemicals ,NADPH oxidase ,biology ,Physiology ,Chemistry ,respiratory system ,Cell biology ,Paracrine signalling ,cardiovascular system ,biology.protein ,Secretion ,Platelet ,Platelet activation ,Receptor ,Autocrine signalling ,NOx ,circulatory and respiratory physiology - Abstract
NADPH-oxidase (NOX) is a novel transmembrane enzyme that appears to have pivotal role in the control of platelet signal pathways. The NOX activity in platelets is controlled by agonist receptors activation, which, in turn are modulated by NOX. This review focuses on participation of NOX in autocrine and paracrine regulation of platelet activation, aggregation secretion, protein synthesis and cell recruitment processes during thrombus formation. Possible involving of NOX in the cell-to-cell communication and coordination in response to trombogenic stimulus is discussed.
- Published
- 2013
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