1. Viburnumfocesides A – D, 1-O-isovaleroylated iridoid 11-O-alloside derivatives from Viburnum foetidum var. ceanothoides.
- Author
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Wang, Dongmei, Yang, Yun, Shi, Xiaoke, Yang, Kaitai, Yin, Kaipu, Wang, Fei, Zhang, Guolin, and Luo, Yinggang
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CELL lines , *ESTROGEN , *HIGH performance liquid chromatography , *LIQUID chromatography , *MOLECULAR structure , *NUCLEAR magnetic resonance spectroscopy , *RESEARCH funding , *SPECTRUM analysis , *WESTERN immunoblotting , *PLANT extracts , *AROMATASE inhibitors , *GRANULOSA cell tumors , *PHARMACODYNAMICS - Abstract
Viburnumfocesides A - D, four undescribed 1- O -isovaleroylated iridoid 11- O -allosides modified with (Z / E)- p -coumaric acid, were isolated from the aqueous EtOH extract of the twigs of Viburnum foetidum var. ceanothoides , together with seven known natural products. Their structures were identified on the basis of the spectroscopic data interpretation and chemical derivation studies. Cell-based estrogen biosynthesis assays indicated that viburnumfoceside D (4), (2 S ,3 R)-2,3-dihydro-3-hydroxymethyl-7-methoxy-2-(4-hydroxy-3-methoxyphenyl)-5-benzofuranpropanol-3a- O - α -L-rhamnopyranoside (8), and (-)-eriodictyol (11) inhibit estrogen biosynthesis with IC 50 values of 5.8, 1.5, and 1.1 μM, respectively, in human ovarian granulosa-like KGN cells via decreasing the expression level of aromatase. Unlabelled Image [ABSTRACT FROM AUTHOR]
- Published
- 2020
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