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2 results on '"Waleed S. Koko"'

1. Evaluation of oral therapy on Mansonial Schistosomiasis using single dose of Balanites aegyptiaca fruits and praziquantel

Author

H.S. Khalid, H.S. Abdalla, Waleed S. Koko, and M. Galal

Subjects
Male, Veterinary medicine, Snails, Helminthiasis, Administration, Oral, Schistosomiasis, Praziquantel, Feces, Mice, Parasitic Sensitivity Tests, parasitic diseases, Drug Discovery, medicine, Animals, Balanites, Anthelmintic, Anthelmintics, Pharmacology, biology, Plant Extracts, Schistosoma mansoni, General Medicine, medicine.disease, biology.organism_classification, Schistosomiasis mansoni, Fruit, Immunology, Drug Therapy, Combination, Female, Balanites aegyptiaca, Phytotherapy, medicine.drug
Abstract

The efficacy of Balanites aegyptiaca fruit mesocarp was compared with praziquantel in mice infected with Sudanese strain of Schistosoma mansoni. Infected mice were given a single dose of 200 mg/kg body weight of B. aegyptiaca fruit mesocarp and 200 mg/kg b.w. of praziquantel after 6 weeks from the onset of the infection. A significant reduction was observed in EPG (egg count per gram of faeces), eggs burden in tissues and recovery of adult worms (P

Published
2005

2. Anti-inflammatory activities of cucurbitacin E isolated from Citrullus lanatus var. citroides: role of reactive nitrogen species and cyclooxygenase enzyme inhibition

Author

Siddig Ibrahim Abdelwahab, Putri Narrima, Manal Mohamed Elhassan Taha, A. Hamid A. Hadi, Syahida Ahmad, Sakina M. Ahmed Yagi, Waleed S. Koko, Loiy Elsir Ahmed Hassan, Hasnah Mohd Sirat, Cheah Shiau Chuen, Mohd Mustafa Rais, and Syam Mohan

Subjects
Lipopolysaccharides, Citrullus lanatus, medicine.drug_class, Anti-Inflammatory Agents, Pharmacology, Carrageenan, Nitric Oxide, Anti-inflammatory, Cell Line, Citrullus, chemistry.chemical_compound, Interferon-gamma, Mice, Drug Discovery, medicine, Animals, Edema, Humans, Cyclooxygenase Inhibitors, Cytotoxicity, Reactive nitrogen species, Cucurbitacin E, chemistry.chemical_classification, Inflammation, biology, Cyclooxygenase 2 Inhibitors, Plant Extracts, General Medicine, biology.organism_classification, Reactive Nitrogen Species, Triterpenes, Enzyme, NG-Nitroarginine Methyl Ester, chemistry, Mechanism of action, Biochemistry, biology.protein, Cyclooxygenase, medicine.symptom, Phytotherapy
Abstract

The in vivo and in vitro mechanistic anti-inflammatory actions of cucurbitacin E (CE) (Citrullus lanatus var. citroides) were examined. The results showed that LPS/INF-γ increased NO production in RAW264.7 macrophages, whereas L-NAME and CE curtailed it. CE did not reveal any cytotoxicity on RAW264.7 and WRL-68 cells. CE inhibited both COX enzymes with more selectivity toward COX-2. Intraperitoneal injection of CE significantly suppressed carrageenan-induced rat's paw edema. ORAC and FRAP assays showed that CE is not a potent ROS scavenger. It could be concluded that CE is potentially useful in treating inflammation through the inhibition of COX and RNS but not ROS.

Published
2011

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