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Your search keyword '"Ding, Liqin"' showing total 7 results
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7 results on '"Ding, Liqin"'

3. Monoterpenoid inhibitors of NO production from Paeonia suffruticosa

Author

Yue Liu, Xin-Sheng Yao, Feng Zhao, Zhihu Jiang, Feng Qiu, Qian Zhao, Ding Liqin, and Lixia Chen

Subjects
Pharmacology, chemistry.chemical_classification, Lipopolysaccharides, Ethanol, biology, Molecular Structure, Stereochemistry, Monoterpene, Paeonia suffruticosa, Glycoside, General Medicine, Nitric oxide metabolism, biology.organism_classification, Nitric Oxide, Paeonia, Nitric oxide, chemistry.chemical_compound, Mice, chemistry, Drug Discovery, Monoterpenes, Animals, No production, Spectral data
Abstract

Three pairs of monoterpene glycosides (1-6), of which compounds 1, 3, and 4 as new compounds, together with one new monoterpene (7) were obtained from the ethanol extract of Paeonia suffruticosa Andrews. Their structures were determined on the basis of chemical methods and spectral data. On this basis, the spectral characteristics of three pairs of monoterpene glycosides were also discussed. The inhibitory effects of isolated compounds on nitric oxide (NO) production in lipopolysaccharide-activated macrophages were evaluated, and NO production was suppressed significantly by compounds 4-7.

Published
2012

6. Sesquiterpenes from the essential oil of Curcuma wenyujin and their inhibitory effects on nitric oxide production.

Author

Xia, Guiyang, Zhou, Li, Ma, Jianghao, Wang, Ying, Ding, Liqin, Zhao, Feng, Chen, Lixia, and Qiu, Feng

Subjects
*ALTERNATIVE medicine, *ANIMAL experimentation, *ANTI-inflammatory agents, *BIOLOGICAL models, *PHYSICAL & theoretical chemistry, *ESSENTIAL oils, *MACROPHAGES, *MEDICINAL plants, *MICE, *NITRIC oxide, *SPECTRUM analysis, *VEGETABLE oils, *PLANT extracts, *DESCRIPTIVE statistics, *IN vitro studies, *PHARMACODYNAMICS
Abstract

Three new sesquiterpenes including a new elemane-type sesquiterpene, 5 βH -elem-1,3,7,8-tetraen-8,12-olide ( 1 ), and two new carabrane-type sesquiterpenes, 7 α ,11-epoxy-6 α -methoxy-carabrane-4,8-dione ( 2 ) and 8,11-epidioxy-8-hydroxy-4-oxo-6-carabren ( 3 ), together with eight known sesquiterpenes ( 4 – 11 ) were isolated from Curcuma wenyujin Y. H. Chen et C. Ling. Their structures were elucidated based on extensive spectroscopic analyses. A possible biogenetic scheme for the related compounds was postulated. All of the isolated compounds were tested for inhibitory activity against LPS-induced nitric oxide production in RAW 264.7 macrophages. Meanwhile, preliminary structure–activity relationships for these compounds are discussed. [ABSTRACT FROM AUTHOR]

Published
2015
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7. New cytotoxic withanolides from Physalis minima.

Author

Zhang, Meng, Jiang, Benke, He, Xinya, Cao, Shijie, Ding, Liqin, Kang, Ning, Chen, Lixia, and Qiu, Feng

Subjects
*ANTINEOPLASTIC agents, *APOPTOSIS, *CELL lines, *INFRARED spectroscopy, *LIQUID chromatography, *MEDICINAL plants, *MELANOMA, *MOLECULAR structure, *NUCLEAR magnetic resonance spectroscopy, *RESEARCH funding, *PLANT extracts, *ELECTROSPRAY ionization mass spectrometry, *PHYTOSTEROLS, *IN vitro studies, *PHARMACODYNAMICS
Abstract

Phytochemical investigation of Physalis minima led to the isolation of six new withanolides, including physaminilides H K (1 – 4), two artificial withanolides (5–6), and 19 known ones (7–25). Their structures were elucidated on the basis of spectroscopic analysis, including NMR and electronic circular dichroism (ECD) data. The isolates were evaluated for their cytotoxic activities against A375 human melanoma cells. Compounds 1 , 8 – 9 , 12 – 13 , 15 – 17 and 19 exhibited significant cytotoxic activities with IC 50 values in the range of 1.2–7.5 μM. Unlabelled Image • Six new withanolides, including physaminilides H K, two artificial withanolides were isolated from Physalis minima L. • New withanolides were determined by NMR and ECD spectra. • Some compounds possessed significant cytotoxic activities. [ABSTRACT FROM AUTHOR]

Published
2020
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