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Your search keyword '"Borrelli F"' showing total 4 results
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4 results on '"Borrelli F"'

1. Effect of a propolis extract and caffeic acid phenethyl ester on formation of aberrant crypt foci and tumors in the rat colon

Author

Borrelli F, Di Carlo G, Maffia P, Russo A, Maiello FM, Capasso F, MASCOLO, NICOLA DOMENICO C. FERDINANDO, BORRELLI, FRANCESCA, IZZO, ANGELO ANTONIO, Borrelli, F, Izzo, ANGELO ANTONIO, Di Carlo, G, Maffia, P, Russo, A, Maiello, Fm, Capasso, F, Mascolo, NICOLA DOMENICO C. FERDINANDO, Borrelli, Francesca, Borrelli, F., Izzo, A. A., DI CARLO, G., Maffia, Pasquale, Russo, A., Maiello, F. M., and Capasso, F.

Subjects
Male, Colon, education, Azoxymethane, digestive system, Propolis, chemistry.chemical_compound, Random Allocation, Caffeic Acids, In vivo, Drug Discovery, medicine, Caffeic acid, Animals, Anticarcinogenic Agents, Rats, Wistar, Caffeic acid phenethyl ester, Anticarcinogen, Pharmacology, Plant Extracts, General Medicine, Phenylethyl Alcohol, Molecular biology, digestive system diseases, Rats, chemistry, Mechanism of action, Biochemistry, Colonic Neoplasms, population characteristics, medicine.symptom, geographic locations, Aberrant crypt foci, Phytotherapy
Abstract

We have studied the effect of propolis and its main active ingredient caffeic acid phenetyl ester (CAPE) on formation of aberrant crypt foci (ACF) and tumors in the rat colon in vivo. CAPE (50 mg/kg i.p.) reduced the formation of ACF and tumor induced by azoxymethane, while propolis ethanolic extract was without effect. These results suggest a potential anti-carcinogenesis of CAPE but not propolis.

Published
2002

3. A new acetophenone derivative from flowers of Helichrysum italicum (Roth) Don ssp. italicum.

Author

Rigano D, Formisano C, Pagano E, Senatore F, Piacente S, Masullo M, Capasso R, Izzo AA, and Borrelli F

Subjects
Animals, Anti-Inflammatory Agents chemistry, Antioxidants chemistry, Cell Line, Humans, Macrophages drug effects, Mice, Oxidative Stress, Reactive Oxygen Species metabolism, Acetophenones chemistry, Epithelial Cells drug effects, Flowers chemistry, Helichrysum chemistry
Abstract

A new acetophenone derivative named gnaphaliol 9-O-propanoate (1) was isolated from the chloroform fraction of EtOH extract of Helichrysum italicum ssp. italicum flowers along with the five known acetophenones 12-acetoxytremetone (2), 13-(2-methylpropanoyloxy)toxol (3), [2,3-dihydro-2-[1-(hydroxymethyl)ethenyl]-5-benzofuranyl]-ethanone (4), 1-[2-[1-[(acetyloxy)methyl]ethenyl]-2,3-dihydro-3-hydroxy-5-benzofuranyl]-ethanone (5) and gnaphaliol (6). The structures of compounds 1-6 were elucidated by extensive spectroscopic methods including 1D- ((1)H and (13)C) and 2D-NMR (DQF-COSY, HSQC, HMBC, TOCSY and ROESY) experiments as well as ESIMS analysis. The isolated compounds were investigated for their cytotoxicity, anti-inflammatory and antioxidant properties. Biological assays on human colonic epithelial cells showed that compound 2 possessed antioxidant effects reducing reactive oxygen species (ROS) production., (Copyright © 2014 Elsevier B.V. All rights reserved.)

Published
2014
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4. The role of the phenethyl ester of caffeic acid (CAPE) in the inhibition of rat lung cyclooxygenase activity by propolis.

Author

Rossi A, Longo R, Russo A, Borrelli F, and Sautebin L

Subjects
Animals, Anti-Inflammatory Agents administration & dosage, Caffeic Acids administration & dosage, Cyclooxygenase Inhibitors administration & dosage, Cyclooxygenase Inhibitors pharmacology, Dinoprost metabolism, Dinoprostone metabolism, Dose-Response Relationship, Drug, Flavonoids administration & dosage, Flavonoids pharmacology, Inhibitory Concentration 50, Lipopolysaccharides, Lung drug effects, Male, Phenylethyl Alcohol administration & dosage, Plant Extracts administration & dosage, Plant Extracts pharmacology, Propolis administration & dosage, Rats, Rats, Wistar, Anti-Inflammatory Agents pharmacology, Caffeic Acids pharmacology, Lung enzymology, Phenylethyl Alcohol analogs & derivatives, Phenylethyl Alcohol pharmacology, Phytotherapy, Propolis pharmacology, Prostaglandin-Endoperoxide Synthases drug effects
Abstract

In this study we investigated the effect of an ethanolic extract of propolis, with and without CAPE, and some of its components on cyclooxygenase (COX) activity. Propolis (0.00003-0.03%) significantly and concentration-dependently inhibited COX activity from lung homogenate of saline- or LPS-treated rats. Same results were obtained with CAPE (0.1-100 microM). COX activity from lung homogenate of saline- or LPS-treated rats was also inhibited by galangin (0.1-100 microM), although the inhibition induced by the lowest concentration was not significant. Caffeic, ferulic, cinnamic and chlorogenic acids and pinocembrin, (0.1-100 microM) did not affect COX activity. The inhibition curves showed that CAPE and propolis were equipotent inhibitors, whereas galangin was significantly (P<0.001) less potent than propolis and CAPE. In order to better investigate the role of CAPE, we tested the action of an ethanolic extract of propolis (0.00003-0.03%) without CAPE. This extract significantly and concentration-dependently inhibited COX activity from lung homogenate of saline- or LPS-treated rats, however, it resulted to be approximately 10 times less potent than the extract containing CAPE. The analysis of the inhibition curves of the extract with and without CAPE showed a significant (P<0.001) difference. These results suggest that both CAPE and galangin contribute to the overall activity of propolis, CAPE being more effective.

Published
2002
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