1. Cryptocaryoic acids A – C: New phenyl alkyl acids isolated from the leaves of Australian rainforest plant Cryptocarya mackinnoniana.
- Author
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Raju, Ritesh, Gunawardena, Dhanushka, Reddell, Paul, and Münch, Gerald
- Subjects
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ANTI-inflammatory agents , *MACROPHAGES , *PHYTOCHEMICALS , *INTERFERONS , *LEAVES , *TUMOR necrosis factors , *NATURE , *NITRIC oxide , *SPECTRUM analysis , *PHARMACODYNAMICS - Abstract
Phytochemical investigation of the leaves of the Australian rainforest tree Cryptocarya mackinnoniana led to the discovery of three new oxygenated phenyl alkyl acids, cryptocaryoic acids A – C and two known compounds, cryptocaryone and 2′,6′-dihydroxy-4′-methoxychalcone. The structures of all the compounds were determined by detailed spectroscopic analysis. Mosher's analysis was used for absolute stereochemistry determination at C-11, while the remaining stereochemistry determination of the one remaining stereocenter C-13 was based on NOESY correlations. All compounds isolated were also evaluated for their anti-inflammatory properties by assessing their inhibitory effects on LPS and interferon-γ induced nitric oxide (NO) production and TNF- α release in RAW 264.7 macrophages. The new cryptocaryoic acids exhibited weak to moderate anti-inflammatory activity (NO inhibition) ranging from (18.4–56 μM). [Display omitted] • Three new phenyl alkyl acids, cryptocaryoic acids A – C, were isolated from the leaves of Cryptocarya mackinnoniana • Cryptocaryoic acids exhibited weak to moderate anti-inflammatory activity • Cryptocaryoic acids are the first in the series of molecules bearing the phenyl oxy-alkyl acid from C.mackinnoniana [ABSTRACT FROM AUTHOR]
- Published
- 2022
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