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Your search keyword '"Qin, Qi-Wei"' showing total 15 results
Start Over Author "Qin, Qi-Wei" Journal fish & shellfish immunology
15 results on '"Qin, Qi-Wei"'

2. Identification and characterization of lncRNAs and the interaction of lncRNA-mRNA in Epinephelus coioides induced with Singapore grouper iridovirus infection

Author

He, Jia-Yang, primary, Yang, Liu, additional, Huang, Wei, additional, Xu, Yu-Min, additional, Cui, Zong-Bin, additional, Liang, Jun-Han, additional, Sun, Ji-Jia, additional, Huang, Xiao-Hong, additional, Huang, You-Hua, additional, Chen, Xiao, additional, Qin, Qi-Wei, additional, and Sun, Hong-Yan, additional

Published
2022
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4. Epinephelus coioides PCSK9 affect the infection of SGIV by regulating the innate immune response

Author

Cai, Yi-Jie, primary, Li, Pin-Hong, additional, Wang, Xiao-Ai, additional, Xu, Yu-Min, additional, Yang, Shan, additional, Tang, Yan-Na, additional, Zhu, Zheng, additional, Yang, Xin-Yue, additional, He, Jia-Yang, additional, Luo, Hao, additional, Zhang, Tong, additional, Qi, Hong, additional, Chen, Xiao, additional, Qin, Qi-Wei, additional, and Sun, Hong-Yan, additional

Published
2022
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11. A novel MKK gene (EcMKK6) in Epinephelus coioides: Identification, characterization and its response to Vibrio alginolyticus and SGIV infection

Author

Su, Yu-Ling, primary, Chen, Jin-Peng, additional, Mo, Ze-Quan, additional, Zheng, Jia-Ying, additional, Lv, Shun-You, additional, Li, Pin-Hong, additional, Wei, Yu-Si, additional, Liang, Yu-Lin, additional, Wang, Shao-Wen, additional, Yang, Min, additional, Dan, Xue-Ming, additional, Huang, Xiao-Hong, additional, Huang, You-Hua, additional, Qin, Qi-Wei, additional, and Sun, Hong-Yan, additional

Published
2019
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12. Effects of antimicrobial peptides on serum biochemical parameters, antioxidant activity and non-specific immune responses in Epinephelus coioides

Author

Su, Yu-Ling, primary, Chen, Guo, additional, Chen, Liang-Shi, additional, Li, Jia-Zhou, additional, Wang, Gang, additional, He, Jia-Yang, additional, Zhan, Tian-Yong, additional, Li, Yan-Wei, additional, Yan, Mu-Ting, additional, Huang, You-Hua, additional, Qin, Qi-Wei, additional, Dan, Xue-Ming, additional, and Sun, Hong-Yan, additional

Published
2019
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14. Epinephelus coioides Sec3 promotes Singapore grouper iridovirus infection by negatively regulates immune response.

Author

Lei, Yu-Rong, He, Jia-Yang, Fu, Xue-Mei, Huang, Cui-Fen, Lin, Yun-Xiang, Dai, Li-Ling, Chen, Zi-An, Zhang, Ze-Peng, Liu, Fu-Min, Qin, Qi-Wei, and Sun, Hong-Yan

Subjects
*MARINE fishes, *GENE expression, *CELL physiology, *VIRAL genes, *CELL survival
Abstract

Exocyst, a protein complex, plays a crucial role in various cellular functions, including cell polarization, migration, invasion, cytokinesis, and autophagy. Sec3, known as Exoc1, is a key subunit of the Exocyst complex and can be involved in cell survival and apoptosis. In this study, two subtypes of Sec 3 were isolated from Epinephelus coioides , an important marine fish in China. The role of E. coioides Sec 3 was explored during Singapore grouper iridovirus (SGIV) infection, an important pathogen of marine fish which could induce 90 % mortality. E. coioides Sec 3 sequences showed a high similarity with that from other species, indicating the presence of a conserved Sec 3 superfamily domain. E. coioides Sec 3 mRNA could be detected in all examined tissues, albeit at varying expression levels. SGIV infection could upregulate E. coioides Sec 3 mRNA. Upregulated Sec 3 significantly promoted SGIV-induced CPE, and the expressions of viral key genes. E. coioides Sec 3 could inhibit the activation of NF-κB and AP-1, as well as SGIV-induced cell apoptosis. The results illustrated that E. coioides Sec 3 promotes SGIV infection by regulating the innate immune response. • Two subtypes of Sec3 from Epinephelus coioides was identified and characterized. • The expression of E. coioides Sec3 was up-regulated during SGIV infection. • E. coioides Sec3 promoted the replication of SGIV and negatively regulates immune response. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Dual-specificity phosphatase 1 inhibits Singapore grouper iridovirus replication via regulating apoptosis in Epinephelus coioides.

Author

He, Jia-Yang, Cai, Yi-Jie, Li, Yong-Xuan, Huang, Wei, Zhang, Yue, Liu, Ke-Jian, Sun, Zhuo, Dai, Li-Ling, Qin, Qi-Wei, and Sun, Hong-Yan

Subjects
*EPINEPHELUS, *MITOGEN-activated protein kinase phosphatases, *GROUPERS, *APOPTOSIS, *VIRUS diseases, *HOMEOSTASIS, *AMINO acids
Abstract

The dual-specificity phosphatase (DUSP) family plays key roles in the maintenance of cellular homeostasis and apoptosis etc. In this study, the DUSP member DUSP1 of Epinephelus coioides was characterized: the length was 2371 bp including 281 bp 5′ UTR, 911 bp 3′ UTR, and a 1125 bp open reading frame encoding 374 amino acids. E. coioides DUSP1 has two conserved domains, a ROHD and DSPc along with a p38 MAPK phosphorylation site, localized at Ser308. E. coioides DUSP1 mRNA can be detected in all of the tissues examined, and the subcellular localization showed that DUSP1 was mainly distributed in the nucleus. Singapore grouper iridovirus (SGIV) infection could induce the differential expression of E. coioides DUSP1. Overexpression of DUSP1 could inhibit SGIV-induced cytopathic effect (CPE), the expressions of SGIV key genes, and the viral titers. Overexpression of DUSP1 could also regulate SGIV-induced apoptosis, and the expression of apoptosis-related factor caspase 3. The results would be helpful to further study the role of DUSP1 in viral infection. • The character Epinephelus coioides DUSP1 was analyzed. • E. coioides DUSP5 regulated the infection and replication of SGIV. • E. coioides DUSP5 regulated the SGIV-induced cell apoptosis. [ABSTRACT FROM AUTHOR]

Published
2024
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