Search

Objective: To examine the validity of self-reported endometriosis and to improve the reliability of questionnaires by including endometriosis-related questions., Design: Analysis of survey questionnaire data., Setting: Cross-sectional study., Patient(s): Cohort of 26, 898 female twins aged 20-60 years at interview, who participated in either of two surveys (1998-2002 or 2005-2006)., Intervention(s): None., Main Outcome Measure(s): Endometriosis diagnosis in the Swedish National Inpatient Registry (IPR)., Result(s): The self-reported endometriosis diagnoses and endometriosis-related questions from a nationwide population-based twin registry were linked with the IPR. Fairly good agreement was found between the self-reported and IPR data on endometriosis. The receiver operating characteristics (ROC) curves showed fairly good predictive ability of self-reported endometriosis to have a confirmed endometriosis diagnosis in the IPR with an area under the curve (AUC) 0.79 (95% confidence interval [CI], 0.77-0.81). Further, the predictive ability increased to AUC 0.89 (95% CI, 0.88-0.90) when there was additional information about infertility and age., Conclusion(s): Our results indicate that self-reported data on endometriosis are moderately accurate and may be useful in studies when register data are not available., (Copyright © 2016 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.)

Objective: To estimate the relative contribution of genetic influences and prevalence on endometriosis., Design: Analysis of self-reported data from a nationwide population-based twin registry., Setting: Not applicable., Patient(s): A total of 28,370 women, female monozygotic (MZ) or dizygotic (DZ) twins, who participated in either of two surveys (1998-2002 or 2005-2006)., Intervention(s): None., Main Outcome Measure(s): Self-reported endometriosis, validated by medical records., Result(s): A history of endometriosis was reported by 1,228 female twins. The probandwise concordance was 0.21 for MZ and 0.10 for DZ twins. Higher within-pair (tetrachoric) correlation was observed among MZ (0.47) compared with DZ (0.20) twins. The best-fitting model revealed a contribution of 47% by additive genetic factors and the remaining 53% attributed to unique environmental effects., Conclusion(s): Our findings suggest both genetic and unique (nonshared) environmental influences on the complex etiology of endometriosis and support the hypothesis that genes have a strong influence on phenotypic manifestations of endometriosis., (Copyright © 2015 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.)