1. Intravenous immunoglobulin preceding in vitro fertilization-embryo transfer for patients with repeated failure of embryo transfer
- Author
-
José Font, Francsico Fäbregues, Montserrat Creus, Juan A. Vanrell, Juan Balasch, and Jaume Martorell
- Subjects
Adult ,Infertility ,medicine.medical_specialty ,Pregnancy Rate ,medicine.medical_treatment ,Fertilization in Vitro ,Immunoglobulin E ,Pregnancy ,Internal medicine ,Humans ,Medicine ,Embryo Implantation ,Prospective Studies ,Treatment Failure ,Prospective cohort study ,In vitro fertilisation ,biology ,business.industry ,Immunoglobulins, Intravenous ,Obstetrics and Gynecology ,Embryo Transfer ,medicine.disease ,Embryo transfer ,Surgery ,Pregnancy rate ,Reproductive Medicine ,biology.protein ,Female ,Antibody ,business ,Infertility, Female - Abstract
Objective To determine the effectiveness of immunotherapy with high-dose IV immunoglobulin preceding IVF-ET for patients with repeated failure of ET. Design Prospective, observational. Setting Assisted Reproduction Unit of the Hospital Clinic i Provincial in Barcelona, a tertiary care setting. Patients Twelve consecutive tubal infertility patients experiencing repeated unexplained IVF-ET failure including at least three ETs replacing three to four fresh embryos each. Two women shared three or more human leukocyte antigens (HLA) with the husband. Intervention During the subsequent new IVF-ET cycle, each patient received 400 mg/kg IV immunoglobulin daily for 5 days during ovarian stimulation, that is, 5 to 7 days before ET. Main Outcome Measures Clinical pregnancies. Results No implantation occurred. There were no side effects. Conclusions High-dose IV immunoglobulin is not a useful tool for IVF-ET failure.
- Published
- 1996
- Full Text
- View/download PDF