1. Preliminary study on the role of the human IZUMO gene in oocyte-spermatozoa fusion failure
- Author
-
Jacques Chouteau, Isabelle Aknin-Seifer, Viviana Granados-Gonzalez, Jean-Philippe Wolf, Renaud-Lauriam Touraine, and Rachel Levy
- Subjects
Infertility ,Male ,Immunoglobulins ,Pilot Projects ,Fertilization in Vitro ,Biology ,Polymorphism, Single Nucleotide ,Andrology ,Exon ,Human fertilization ,Polymorphism (computer science) ,Pregnancy ,Genotype ,medicine ,Humans ,Genetic Predisposition to Disease ,Gene ,Cells, Cultured ,Infertility, Male ,Pregnancy Outcome ,Obstetrics and Gynecology ,Membrane Proteins ,Exons ,medicine.disease ,Oocyte ,Spermatozoa ,medicine.anatomical_structure ,Reproductive Medicine ,Fertilization ,Oocytes ,Female ,Fusion failure - Abstract
We studied the IZUMO gene 9 coding exons sequence in four groups of patients including those with fertilization failure by conventional IVF. We observed in our populations two combinations of four polymorphisms that appeared to be preferentially linked (CGG-CG and TAA-TT) without any significant difference between different genotype repartitions.
- Published
- 2007