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The purpose of the experiment was to study the effects of three unconventional fermented feeds on pig growth, serum biochemical indexes and antibody levels. The experiment divided 48 pigs into four groups, with 12 replicates in each group and one pigs in each replicate. The pigs in control group (group A) were fed the basal diet, and 30% unconventional fermented feeds B (3% soybean meal +10% corn +10% fish sauce +3% garlic skin +4% premix), C (3% soybean meal + 11% corn + 12% mango peel + 4% premix) and D (15% corn + 11% mango peel + 4% premix) were added to the basal diet in group B, group C and group D, respectively. The experimental period was 30 d. The results showed that compared with control group, the feed intake of group B and group D was significantly increased ( P<0.05), and the weight gain was extremely decreased ( P<0.01). The feed weight gain cost of group B and group D was 20.37% and 42.40% higher than that of control group, and the feed weight gain cost of group C was 3.17% lower than that of control group. Compared with control group, the serum TP, TC and TG content of pigs in group B were significantly increased (P<0.05), LDH activity and LDL-C content were extremely increased (P<0.01). The content of HDL-C in group D was significantly decreased ( P<0.05), and the content of LDL-C was significantly increased (P<0.05). Compared with control group, the serum PR-gB antibody level in group D was significantly increased ( P<0.05) and reached a positive level. The serum PR-gE antibody, PRRS antibody and PCVD antibody levels in group B were the lowest among all groups, and PR-gE antibody and PCVD antibody level was extremely lower than that of control group ( P<0.01). The serum PR-gE antibody level of group B was extremely lower than that of group C and group D ( P<0.01), and the level of PRRS antibody was extremely significantly lower than that of group D ( P<0.01). The study indicates that group C had the best production effect and cost-effectiveness, group B had the best disease resistance effect, and unconventional fermented feed C could be used as a substitute for the basal diet. [ABSTRACT FROM AUTHOR]