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2 results on '"retinoblastoma protein family"'

1. HPV E7 viral oncoprotein disrupts transcriptional regulation of L1Md retrotransposon

Author

Montoya-Durango, Diego E. and Ramos, Kenneth S.

Subjects
*RETROTRANSPOSONS, *GENETIC transcription, *GENETIC regulation, *RETINOBLASTOMA, *PAPILLOMAVIRUS diseases, *HISTONE deacetylase, *DNA methyltransferases
Abstract

Abstract: Murine L1Md-A5 retrotransposon is a redox-inducible element regulated by Nrf-2/JunD and E2F/Rb-binding sites within its promoter (5′-UTR). Because the human papillomavirus (HPV) oncoprotein E7 interacts with retinoblastoma (pRb) and members of the AP1 family, studies were conducted to examine functional interactions between HPV E7, pRb, and histone deacetylase 2 (HDAC2) in the regulation of L1Md-A5. Using a transient heterologous transcription system we found that HPV E7 alone, or in combination with HDAC2, disrupted pRb-mediated L1MdA-5 transactivation. HPV E7 also ablated the transcriptional response of L1Md-A5 to genotoxic stress, but did not interfere with basal activity. We conclude that HPV E7 associates with proteins involved in the assembly of macromolecular complexes that regulate antioxidant and E2F/Rb sites within L1MdA-5 to regulate biological activity [Copyright &y& Elsevier]

Published
2012
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2. HPV E7 viral oncoprotein disrupts transcriptional regulation of L1Md retrotransposon

Author

Diego E. Montoya-Durango and Kenneth S. Ramos

Subjects
Retroelements, Biophysics, Histone Deacetylase 2, Biology, Alphapapillomavirus, Biochemistry, Retinoblastoma Protein, Article, Long interspersed nuclear element (LINE1 or L1), 03 medical and health sciences, Transactivation, Mice, 5′-Untranslated region (5′-UTR), 0302 clinical medicine, Structural Biology, Genes, Reporter, Genetics, Transcriptional regulation, Benzo(a)pyrene, Animals, Humans, E2F, Luciferases, Promoter Regions, Genetic, Molecular Biology, 030304 developmental biology, 0303 health sciences, Histone deacetylase 2, Retinoblastoma protein, Cell Biology, Oncogene Proteins, Viral, Benzo(a)pyrene (BaP), E7 viral oncoprotein, 3. Good health, E2F Transcription Factors, AP-1 transcription factor, Long Interspersed Nucleotide Elements, Gene Expression Regulation, Cancer research, biology.protein, Carcinogens, Histone deacetylase, Retinoblastoma protein family, 030217 neurology & neurosurgery, HeLa Cells
Abstract

Murine L1Md-A5 retrotransposon is a redox-inducible element regulated by Nrf-2/JunD and E2F/Rb-binding sites within its promoter (5′-UTR). Because the human papillomavirus (HPV) oncoprotein E7 interacts with retinoblastoma (pRb) and members of the AP1 family, studies were conducted to examine functional interactions between HPV E7, pRb, and histone deacetylase 2 (HDAC2) in the regulation of L1Md-A5. Using a transient heterologous transcription system we found that HPV E7 alone, or in combination with HDAC2, disrupted pRb-mediated L1MdA-5 transactivation. HPV E7 also ablated the transcriptional response of L1Md-A5 to genotoxic stress, but did not interfere with basal activity. We conclude that HPV E7 associates with proteins involved in the assembly of macromolecular complexes that regulate antioxidant and E2F/Rb sites within L1MdA-5 to regulate biological activity

Published
2011

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