1. Sequence and structure similarities of cathepsin B from the parasite Schistosoma mansoni and human liver
- Author
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Mo-Quen Klinkert, Vito Turk, Richard H. Butler, Wolfram Bode, Elliott Shaw, and Donato Cioli
- Subjects
Protein Conformation ,Structural similarity ,Molecular Sequence Data ,Biophysics ,Sequence (biology) ,Biochemistry ,Cathepsin B ,Inhibitor modelling ,Protein structure ,Structural Biology ,parasitic diseases ,Genetics ,Animals ,Humans ,Parasite hosting ,Amino Acid Sequence ,Molecular Biology ,Peptide sequence ,chemistry.chemical_classification ,Sequence Homology, Amino Acid ,biology ,Chemistry ,Structural comparison ,Schistosoma mansoni ,Cell Biology ,biology.organism_classification ,Virology ,Human liver ,Enzyme ,Liver - Abstract
A three-dimensional structure of Schistosoma mansoni cathepsin B was modelled using the coordinates of the crystal structure of the human liver enzyme. Both enzymes appear to share remarkable structural similarity. However, an examination of the models complexed with two synthetic inhibitors revealed differences in inhibitor binding, as confirmed by differences in the 50% inhibitory concentration of the same inhibitor.
- Published
- 1994