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4. Competitive inhibition of the 5-lipoxygenase-catalysed linoleate oxidation by arachidonic and 5-hydroperoxy-eicosatetraenoic acids

Author

Mirzoeva, Olga K., Sud'ina, Galina F., Pushkareva, Marina A., and Varfolomeev, Sergey D.

Abstract

Linoleic and arachidonic acids are competing substrates for 5-1ipoxygenase from barley. When these two substrates are added simultaneously, arachidonic acid acts as a competitive inhibitor of linoleic acid oxidation with Kiof 20 μM, the same value as the Michaelis constant for arachidonate oxygenation by this enzyme (22 ± 3 μM). Linoleic acid hydroperoxide accumulated in the reaction mixture does not inhibit the enzymatic process, while arachidonic acid hydroperoxy product (5-hydroperoxy-6,8,11,14-eicosatetraenoic acid) inhibits it with very low Kiequal to 0.5 μM.

Published
1995
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