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3. Lasp-1 (MLN 50) defines a new LIM protein subfamily characterized by the association of LIM and SH3 domains.

Author

Tomasetto C, Moog-Lutz C, Régnier CH, Schreiber V, Basset P, and Rio MC

Subjects
Adaptor Proteins, Signal Transducing, Amino Acid Sequence, Base Sequence, Blotting, Northern, Chromosomes, Human, Pair 17, Consensus Sequence genetics, Cytoskeletal Proteins, DNA, Complementary genetics, Female, Gene Expression, Homeodomain Proteins biosynthesis, Homeodomain Proteins genetics, Humans, LIM Domain Proteins, Molecular Sequence Data, Neoplasm Metastasis, Protein Kinases genetics, RNA, Messenger biosynthesis, RNA, Messenger genetics, Receptor, ErbB-2 biosynthesis, Sequence Alignment, Sequence Homology, Amino Acid, Breast Neoplasms metabolism, Homeodomain Proteins chemistry, Neoplasm Proteins, src Homology Domains
Abstract

MLN 50 was previously identified in a cDNA library of breast cancer metastasis. In this study, we show that MLN 50, which is expressed at a basal level in normal tissues, is overexpressed in 8% of human breast carcinomas most often together with c-erbB-2. MLN 50 cDNA encodes a putative protein of 261 residues, named Lasp-1 (LIM and SH3 protein) since it contains a LIM motif and a domain of Src homology region 3 (SH3) at the amino- and the C-terminal parts of the protein, respectively. Thus, Lasp-1 defines a new LIM protein subfamily.

Published
1995
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