1. Molecular anatomy of the human glucose 6-phosphate dehydrogenase core promoter
- Author
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Francesca Fusco, Antonietta Santoro, Matilde Valeria Ursini, Maria Immacolata Ferrante, Annamaria Franzè, Giuseppe Martini, Emma Sanzari, Franze', Annamaria, Ferrante, M. I., Fusco, F., Santoro, A., Sanzari, E., Martini, G., and Ursini, M. V.
- Subjects
Transcriptional Activation ,congenital, hereditary, and neonatal diseases and abnormalities ,Sp1 Transcription Factor ,Molecular Sequence Data ,Biophysics ,Mutagenesis (molecular biology technique) ,Dehydrogenase ,Glucosephosphate Dehydrogenase ,Biology ,Biochemistry ,Sp1 ,Cell Line ,chemistry.chemical_compound ,Sp3 transcription factor ,Structural Biology ,hemic and lymphatic diseases ,parasitic diseases ,Genetics ,Animals ,Humans ,Glucose-6-phosphate dehydrogenase ,Housekeeping gene ,Promoter Regions, Genetic ,Molecular Biology ,Gene ,Regulation of gene expression ,Binding Sites ,Base Sequence ,Initiator ,nutritional and metabolic diseases ,Zinc Fingers ,Promoter ,Cell Biology ,Anatomy ,DNA-Binding Proteins ,Sp3 Transcription Factor ,Gene Expression Regulation ,chemistry ,Mutagenesis, Site-Directed ,Glucose 6-phosphate dehydrogenase ,Nucleic Acid Conformation ,Drosophila ,Transcription Factors - Abstract
The gene encoding glucose 6-phosphate dehydrogenase (G6PD), which plays a pivotal role in cell defense against oxidative stress, is ubiquitously expressed at widely different levels in various tissues; moreover, G6PD expression is regulated by a number of stimuli. In this study we have analyzed the molecular anatomy of the G6PD core promoter. Our results indicate that the G6PD promoter is more complex than previously assumed; G6PD expression is under the control of several elements that are all required for correct promoter functioning and, furthermore, a still unidentified mammalian specific factor is needed. Copyright (C) 1998 Federation of European Biochemical Societies.
- Published
- 1998
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