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2. 6-Fluoropyridoxol: A novel probe of cellular pH using 19F NMR spectroscopy

Author

Mehta, Vimal D., Kulkarni, Padmakar V., Mason, Ralph P., Constantinescu, Anca, Aravind, Sivasubramanian, Goomer, Naresh, and Antich, Peter P.

Abstract

6-Fluoropyridoxol was evaluated as an intracellular pH indicator. This molecule exhibits exceptional sensitivity to changes in pH (∼ 10 ppm acid/base shift) and a p Ka∼8.2 appropriate for physiological investigations. Using 19F NMR spectroscopy we determined both intra- and extracellular pH in whole blood and confirmed the measurements using traditional techniques: ion-electrodes and 31P NMR spectroscopy.

Published
1994
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