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Your search keyword '"Kawakami, Yasushi"' showing total 9 results
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9 results on '"Kawakami, Yasushi"'

1. A candidate functional SNP rs7074440 in TCF7L2 alters gene expression through C‐FOS in hepatocytes

Author

Piao, Xianying, Yahagi, Naoya, Takeuchi, Yoshinori, Aita, Yuichi, Murayama, Yuki, Sawada, Yoshikazu, Shikama, Akito, Masuda, Yukari, Nishi‐Tatsumi, Makiko, Kubota, Midori, Izumida, Yoshihiko, Sekiya, Motohiro, Matsuzaka, Takashi, Nakagawa, Yoshimi, Sugano, Yoko, Iwasaki, Hitoshi, Kobayashi, Kazuto, Yatoh, Shigeru, Suzuki, Hiroaki, Yagyu, Hiroaki, Kawakami, Yasushi, and Shimano, Hitoshi

Published
2018
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2. A key role of nuclear factor Y in the refeeding response of fatty acid synthase in adipocytes

Author

Nishi‐Tatsumi, Makiko, Yahagi, Naoya, Takeuchi, Yoshinori, Toya, Naoki, Takarada, Ayako, Murayama, Yuki, Aita, Yuichi, Sawada, Yoshikazu, Piao, Xiaoying, Oya, Yukari, Shikama, Akito, Masuda, Yukari, Kubota, Midori, Izumida, Yoshihiko, Matsuzaka, Takashi, Nakagawa, Yoshimi, Sekiya, Motohiro, Iizuka, Yoko, Kawakami, Yasushi, Kadowaki, Takashi, Yamada, Nobuhiro, and Shimano, Hitoshi

Published
2017
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3. Glucocorticoid receptor suppresses gene expression of Rev‐erbα (Nr1d1) through interaction with theCLOCKcomplex

Author

Murayama, Yuki, primary, Yahagi, Naoya, additional, Takeuchi, Yoshinori, additional, Aita, Yuichi, additional, Mehrazad Saber, Zahra, additional, Wada, Nobuhiro, additional, Li, EnXu, additional, Piao, Xianying, additional, Sawada, Yoshikazu, additional, Shikama, Akito, additional, Masuda, Yukari, additional, Nishi‐Tatsumi, Makiko, additional, Kubota, Midori, additional, Izumida, Yoshihiko, additional, Miyamoto, Takafumi, additional, Sekiya, Motohiro, additional, Matsuzaka, Takashi, additional, Nakagawa, Yoshimi, additional, Sugano, Yoko, additional, Iwasaki, Hitoshi, additional, Kobayashi, Kazuto, additional, Yatoh, Shigeru, additional, Suzuki, Hiroaki, additional, Yagyu, Hiroaki, additional, Kawakami, Yasushi, additional, and Shimano, Hitoshi, additional

Published
2019
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5. A candidate functional SNP rs7074440 inTCF7L2alters gene expression through C-FOS in hepatocytes

Author

Piao, Xianying, primary, Yahagi, Naoya, additional, Takeuchi, Yoshinori, additional, Aita, Yuichi, additional, Murayama, Yuki, additional, Sawada, Yoshikazu, additional, Shikama, Akito, additional, Masuda, Yukari, additional, Nishi-Tatsumi, Makiko, additional, Kubota, Midori, additional, Izumida, Yoshihiko, additional, Sekiya, Motohiro, additional, Matsuzaka, Takashi, additional, Nakagawa, Yoshimi, additional, Sugano, Yoko, additional, Iwasaki, Hitoshi, additional, Kobayashi, Kazuto, additional, Yatoh, Shigeru, additional, Suzuki, Hiroaki, additional, Yagyu, Hiroaki, additional, Kawakami, Yasushi, additional, and Shimano, Hitoshi, additional

Published
2018
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9. PPAR gamma ligands, troglitazone and pioglitazone, up-regulate expression of HMG-CoA synthase and HMG-CoA reductase gene in THP-1 macrophages.

Author

Iida KT, Kawakami Y, Suzuki H, Sone H, Shimano H, Toyoshima H, Okuda Y, and Yamada N

Subjects
Cell Differentiation genetics, Cell Line, Cholesterol metabolism, DNA, Antisense genetics, DNA, Antisense pharmacology, Dose-Response Relationship, Drug, Gene Expression Regulation drug effects, Gene Expression Regulation, Enzymologic drug effects, Humans, Hydroxymethylglutaryl-CoA Synthase, Macrophages cytology, Macrophages metabolism, Oligonucleotides genetics, Oligonucleotides pharmacology, Pioglitazone, RNA, Messenger drug effects, RNA, Messenger genetics, RNA, Messenger metabolism, Receptors, Cytoplasmic and Nuclear agonists, Response Elements genetics, Transcription Factors agonists, Troglitazone, Up-Regulation drug effects, Chromans pharmacology, Coenzyme A Ligases genetics, Hydroxymethylglutaryl CoA Reductases genetics, Macrophages drug effects, Thiazoles pharmacology, Thiazolidinediones
Abstract

Recently it has been reported that macrophages express a nuclear receptor, peroxisome proliferator-activated receptor gamma (PPAR gamma). Using a ligand of PPAR gamma, troglitazone or pioglitazone, we have shown that the expression of two genes involved in cholesterol biosynthesis, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase and HMG-CoA reductase, were increased by activation of PPAR gamma through a PPAR response element (PPRE) in THP-1 macrophages. In addition, treatment with troglitazone significantly increased the activity of HMG-CoA reductase and the amount of intracellular cholesterol. Thus, we conclude that PPAR gamma and its agonists increase the cholesterol content of macrophages by the increased expression of genes involved in cholesterol biosynthesis. These findings suggest that PPAR gamma may play a role in cholesterol metabolism in macrophages.

Published
2002
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