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5 results on '"Iossa, Susanna"'

4. Cold exposure differently influences mitochondrial energy efficiency in rat liver and skeletal muscle

Author

Giovanna Liverini, Susanna Iossa, A. Barletta, Lillà Lionetti, Raffaella Crescenzo, Rosaria Tasso, Maria Pina Mollica, Mollica, MARIA PINA, Lionetti, L, Crescenzo, Raffaella, Tasso, R, Barletta, Antonio, Liverini, Giovanna, and Iossa, Susanna

Subjects
Male, medicine.medical_specialty, Uncoupling Agents, Cold exposure, Biophysics, Palmitates, Mitochondria, Liver, Oxidative phosphorylation, Biology, Mitochondrion, Biochemistry, Ion Channels, Oxidative Phosphorylation, Electron Transport Complex IV, Mitochondrial Proteins, Oxygen Consumption, Structural Biology, Internal medicine, Genetics, medicine, Uncoupling protein, Animals, Uncoupling Protein 3, Rats, Wistar, Muscle, Skeletal, Molecular Biology, UCP3, Skeletal muscle, Thermogenesis, Cell Biology, Fatty acid uncoupling, Thermogenin, Mitochondria, Muscle, Rats, Cold Temperature, Mitochondrial coupling, medicine.anatomical_structure, Endocrinology, Liver, Carrier Proteins, Mitochondrial ADP, ATP Translocases, Body Temperature Regulation
Abstract

This study deals with mitochondrial energy efficiency in liver and skeletal muscle mitochondria in 15 days cold exposed rats. Cold exposure strongly increases the sensitivity to uncoupling by added palmitate of skeletal muscle but not liver mitochondria, while mitochondrial energy coupling in the absence of fatty acids is only slightly affected by cold in liver and skeletal muscle. In addition, uncoupling protein 3 content does not follow changes in skeletal muscle mitochondrial coupling. It is therefore concluded that skeletal muscle could play a direct thermogenic role based on fatty acid-induced mild uncoupling of mitochondrial oxidative phosphorylation.

Published
2005

5. Metabolic efficiency of liver mitochondria in rats with decreased thermogenesis

Author

Susanna Iossa, Monica Botta, Maria Pia Mollica, Lillà Lionetti, Raffaella Crescenzo, Giovanna Liverini, S., Iossa, M. P., Mollica, L., Lionetti, Crescenzo, Raffaella, M., Botta, G., Liverini, Iossa, Susanna, Mollica, Mp, Lionetti, L, Botta, M, and Liverini, Giovanna

Subjects
Male, medicine.medical_specialty, Hot Temperature, Time Factors, Palmitate-induced uncoupling, Biophysics, Palmitic Acid, Mitochondria, Liver, Mitochondrion, Biology, Atractyloside, Biochemistry, Acclimatization, Membrane Potentials, Electron Transport Complex IV, Basal (phylogenetics), Oxygen Consumption, Structural Biology, Serum free, Internal medicine, Genetics, medicine, Animals, Basal proton leak, Rats, Wistar, Molecular Biology, Triiodothyronine, Dose-Response Relationship, Drug, Fatty Acids, Temperature, Biological Transport, Cell Biology, Fasting, Mitochondrial efficiency, Metabolic efficiency, Rats, Kinetics, Endocrinology, Liver, Protons, Whole body, Thermogenesis
Abstract

We have studied changes in hepatic mitochondrial efficiency induced by 24-h fasting or acclimation at 29 degrees C, two conditions of reduced thermogenesis. Basal and palmitate-induced proton leak, which contribute to mitochondrial efficiency, are not affected after 24-h fasting, when serum free triiodothyronine decreases significantly and serum free fatty acids increase significantly. In rats at 29 degrees C, in which serum free triiodothyronine and fatty acids decrease significantly, basal proton leak increases significantly, while no variation is found in palmitate-induced proton leak. The present results indicate that mitochondrial efficiency in the liver is not related to a physiological decrease in whole body thermogenesis.

Published
2003

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