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9 results on '"Gumaa, K. A."'

1. Thyroid hormone control of cyclic nucleotide phosphodiesterases and the regulation of the sensitivity of the liver to hormones.

Author

Gumaa KA, Hothersall JS, Greenbaum AL, and McLean P

Subjects
Adenylyl Cyclases metabolism, Animals, Body Weight, Cell Membrane enzymology, Cyclic GMP, In Vitro Techniques, Kinetics, Male, Organ Size, Rats, 3',5'-Cyclic-AMP Phosphodiesterases metabolism, Liver enzymology, Phosphoric Diester Hydrolases metabolism, Thyroidectomy
Published
1977
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2. Modulation of rat pancreatic islet cell replication and insulin release by glibenclamide.

Author

Khatim MS, Al-Mahmood HA, and Gumaa KA

Subjects
Animals, Cell Division drug effects, DNA Replication drug effects, Female, Glucose pharmacology, Islets of Langerhans drug effects, Islets of Langerhans metabolism, Rats, Rats, Inbred Strains, Thymidine metabolism, Glyburide pharmacology, Islets of Langerhans cytology
Abstract

Glibenclamide significantly stimulated the incorporation of [3H]thymidine into DNA of fetal rat pancreatic islets at a physiological (5.5 mM) but not at a high (22 mM) glucose concentration. There was no significant stimulation of insulin release under these conditions. In contrast, the drug-stimulated insulin release from adult islets cultured at 5.5 mM glucose but had no effect on their DNA synthesis. The observations suggest that insulin secretion and DNA synthesis may be dissociated in rat pancreatic islets.

Published
1984
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6. The kinetic quantitation of ATP: D-glucose 6-phosphotransferases.

Author

Gumaa KA and McLean P

Subjects
Adipose Tissue enzymology, Animals, Brain enzymology, Female, Fructose, Glucokinase blood, Glucose, Hexokinase blood, Humans, Isoenzymes metabolism, Kinetics, Lactation, Leukocytes enzymology, Liver enzymology, Lung enzymology, Male, Mammary Glands, Animal enzymology, Mathematics, Pregnancy, Rats, Spectrophotometry, Ultraviolet, Time Factors, Weaning, Glucokinase metabolism, Hexokinase metabolism
Published
1972
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7. Calculation of the intracellular distribution of acetyl CoA and CoA, based on the use of citrate synthase as an equilibrium enzyme.

Author

Gumaa KA, McLean P, and Greenbaum AL

Subjects
Acetates metabolism, Acetyl Coenzyme A analysis, Animals, Carbon Dioxide biosynthesis, Carbon Isotopes, Citrate (si)-Synthase, Cytosol analysis, Female, Glucose metabolism, Lactation, Mammary Glands, Animal cytology, Mammary Glands, Animal enzymology, Mammary Glands, Animal metabolism, Mathematics, Mitochondria analysis, Pregnancy, Pyruvates metabolism, Sheep, Coenzyme A analysis, Mammary Glands, Animal analysis, Oxo-Acid-Lyases
Published
1973
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