1. Novel amphiphilic compounds effectively inactivate the vaccinia virus.
- Author
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Fedorova AA, Goncharova EP, Ryabchikova EI, Vlasov VV, and Zenkova MA
- Subjects
- Cell Line, Ribonucleases metabolism, Time Factors, Vaccinia virus physiology, Antiviral Agents chemistry, Antiviral Agents pharmacology, Biomimetic Materials chemistry, Biomimetic Materials pharmacology, Hydrophobic and Hydrophilic Interactions, Vaccinia virus drug effects, Virus Inactivation drug effects
- Abstract
Recent studies demonstrated the ability of artificial ribonucleases (aRNases, small organic RNA cleaving compounds) to inactivate RNA-viruses via the synergetic effect of viral RNA cleavage and disruption of viral envelope [1,2]. Herein, we describe the antiviral activity of aRNases against DNA-containing vaccinia virus: screening of aRNases of various structures revealed that amphiphilic compounds built of positively charged 1,4-diazabicyclo[2.2.2] octane substituted at the bridge nitrogen atoms with aliphatic residues efficiently inactivate this virus. The first stage was the destruction of viral membrane and structure of surface proteins (electron microscopy data). Thus, 1,4-diazabicyclo[2.2.2] octane-based aRNases are novel universal agents inactivating both RNA- and DNA-containing viruses., (Copyright © 2012. Published by Elsevier B.V.)
- Published
- 2012
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