Search

Your search keyword '"Falzano L"' showing total 2 results
Start Over Author "Falzano L" Journal febs letters
2 results on '"Falzano L"'

2. Glutamate-induced calcium increase in myotubes depends on up-regulation of a sodium-dependent transporter.

Author

Frank C, Giammarioli AM, Falzano L, Fiorentini C, and Rufini S

Subjects
2-Chloroadenosine pharmacology, Amino Acid Transport System X-AG drug effects, Animals, Aspartic Acid analogs & derivatives, Aspartic Acid pharmacology, Biological Transport drug effects, Cell Differentiation drug effects, Cells, Cultured, Cycloheximide pharmacology, Dicarboxylic Acids pharmacology, Glutamate Plasma Membrane Transport Proteins, Mice, Muscle Fibers, Skeletal drug effects, Muscle, Skeletal cytology, Muscle, Skeletal drug effects, Protein Synthesis Inhibitors pharmacology, Purines metabolism, Pyrrolidines pharmacology, Symporters drug effects, Up-Regulation, Amino Acid Transport System X-AG metabolism, Calcium metabolism, Glutamic Acid metabolism, Muscle Fibers, Skeletal metabolism, Muscle, Skeletal metabolism, Symporters metabolism
Abstract

We report a study on the regulation by 2-chloro adenosine (2CA) of a glutamate (Glu) transporter in myogenic C2C12 cells. Long-term 2CA exposition significantly increased the V(max) of the Glu transporter. Moreover, 2CA-treated cells responded to Glu challenge by a rapid and transient increase in their intracellular calcium level. The above reported effects were totally abolished by treating C2C12 cells with the Na(+)-dependent Glu transporter inhibitors DL-threo-b-hydroxyaspartic acid and L-trans-pyrrolidine-2,4-dicarboxylic acid. We propose that the possible link between the Glu uptake increase and the Glu induction of calcium rise could be the depolarizing currents carried by Na(+) coupled with transporter activity.

Published
2002
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results