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3. The potential role of regulator of G-protein signaling 16 in cell motility mediated by δ EF1 family proteins.

Author

Hoshi, Yuta, Endo, Kaori, Shirakihara, Takuya, Fukagawa, Akihiko, Miyazawa, Keiji, and Saitoh, Masao

Subjects
*G proteins, *CELLULAR signal transduction, *CELL motility, *CANCER invasiveness, *GENE expression, *GENETICS of breast cancer
Abstract

The epithelial-mesenchymal transition ( EMT) is associated with tumor progression. We reported previously that expression of the δ EF1 family proteins (δ EF1/ ZEB1 and SIP1/ ZEB2), key regulators of the EMT, is positively correlated with EMT phenotypes and aggressiveness of breast cancer. Here, we show that the expression levels of regulator of G-protein signaling 16 ( RGS16) are negatively correlated with those of the δ EF1 family proteins. On the basis of the results of gain- and loss-of-function analyses, we suggest that δ EF1 family proteins promote cell motility of breast cancer cells directly or indirectly through repressing expression of RGS16. [ABSTRACT FROM AUTHOR] more...

Published
2016
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