1. [The pharmacology of 1-(2-pyrimidinyl)piperazine, a metabolite of buspirone].
- Author
-
Komissarov IV, Dulenko VI, Kharin NA, Tolkunov SV, and Talalaenko AN
- Subjects
- Animals, Anti-Anxiety Agents therapeutic use, Anxiety drug therapy, Buspirone pharmacology, Buspirone therapeutic use, Conflict, Psychological, Diazepam pharmacology, Drug Evaluation, Preclinical, Escape Reaction drug effects, Mice, Muscle Relaxants, Central therapeutic use, Muscle Relaxation drug effects, Rats, Anti-Anxiety Agents pharmacology, Buspirone analogs & derivatives
- Abstract
In experiments on rats the anxiolytic activity of 1-(2-pyrimidinyl)-piperazine (PP) was revealed only in some models of anxiety states, although diazepam was effective in all used models. In contrast to diazepam, PP exerts the anesthetic-potentiating and myorelaxant effects only when administered in subtoxic doses and possesses no anticorazole activity. The facts testifying to the serotoninergic mechanisms of the anxiolytic action of 1-(2-pyrimidinyl)-piperazine are presented.
- Published
- 1989