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On the isolated segments of the ileum of the guinea-pig, anesthetized and nonanesthetized rats and mice it was established that calcium ion antagonists from different chemical series exert the nonspecific antibradykinin action, reducing the main biological effects of bradykinin--myotropic, depressor, nociceptive and microcirculatory. To a greater extent the mentioned properties show up in the derivatives of 1,4-dihydropyridine (phoridon, etc.) that may play the certain role in the therapeutic action of the drugs in the diseases associated with the activation of the kinin system of the organism.

Coordination compounds of methenkephalin with transition metals: copper, cobalt, nickel and zinc were shown to be superior to morphine by the analgesic activity and to morphine and methenkephalin by the duration of the analgesic effect. A more stable relationship between opiate receptors and copper-containing methenkephalin was shown in the experiments on the isolated neuronal membrane.

Tests conducted in vitro and in vivo demonstrated that tropaphen, tropine ether of alpha-phenyl-beta-(p-acetoxyphenyl)-propionic acid, an original alpha-adrenoblocking agent, display a marked antiserotonin activity exceeding that of phentolamine. Moreover, tropaphen is more active that phenolamine by its inhibiting influence on the spasmogenous effects of histamine, angiotensin, bradykinine and prostaglandin E2. In doses of 0.1 and 0.25 mg/kg both drugs had no effect on changes of the arterial pressure in anesthetized rats, caused by the above mentioned biologically active substances.

Naloxone was shown to induce a slight increase of the blood supply to the brain, an elevation of blood pressure and an enhancement of the bioelectrical activity in the sympathetic nerves. Unlike opioid peptides, naloxone was found to exert a marked alleviating effect on the nervous control of the cerebral circulation. The drug increases neurogenic spasms of the cerebral vessels that is followed by an enhancement of vasomotor and somatosympathetic reflexes. The data obtained indicate the role of the opioid system in the central regulation of the cerebral circulation.

Non-narcotic analgesics benzofurocaine and voltaren (10% of LD50) were shown to exert the protective effect on rats in castor oil-induced diarrhea, to decrease in mice the degree of pain reaction under the influence of acetylcholine, acetic acid and thermic stimulation.