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3 results on '"Rosa Guarch"'

1. Multi-site tumor sampling (MSTS) improves the performance of histological detection of intratumor heterogeneity in clear cell renal cell carcinoma (CCRCC) [version 2; referees: 5 approved]

Author

Rosa Guarch, Jesús M. Cortés, Charles H. Lawrie, and José I. López

Subjects
Cancer Therapeutics, Methods for Diagnostic & Therapeutic Studies, Medicine, Science
Abstract

Current standard-of-care tumor sampling protocols for CCRCC (and other cancers) are not efficient at detecting intratumoural heterogeneity (ITH). We have demonstrated in silico that an alternative protocol, multi-site tumor sampling (MSTS) based upon the divide and conquer (DAC) algorithm, can significantly increase the efficiency of ITH detection without extra costs. Now we test this protocol on routine hematoxylin-eosin (HE) sections in a series of 38 CCRCC cases. MSTS was found to outperform traditional sampling when detecting either high grade (p=0.0136) or granular/eosinophilic cells (p=0.0114). We therefore propose that MSTS should be used in routine clinical practice.

Published
2016
Full Text
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2. Multi-site tumor sampling (MSTS) improves the performance of histological detection of intratumor heterogeneity in clear cell renal cell carcinoma (CCRCC) [version 1; referees: 5 approved]

Author

Rosa Guarch, Jesús M. Cortés, Charles H. Lawrie, and José I. López

Subjects
Cancer Therapeutics, Methods for Diagnostic & Therapeutic Studies, Medicine, Science
Abstract

Current standard-of-care tumor sampling protocols for CCRCC (and other cancers) are not efficient at detecting intratumoural heterogeneity (ITH). We have demonstrated in silico that an alternative protocol, multi-site tumor sampling (MSTS) based upon the divide and conquer (DAC) algorithm, can significantly increase the efficiency of ITH detection without extra costs. Now we test this protocol on routine hematoxylin-eosin (HE) sections in a series of 38 CCRCC cases. MSTS was found to outperform traditional sampling when detecting either high grade (p=0.0136) or granular/eosinophilic cells (p=0.0114). We therefore propose that MSTS should be used in routine clinical practice.

Published
2016
Full Text
View/download PDF

3. Multi-site tumor sampling (MSTS) improves the performance of histological detection of intratumor heterogeneity in clear cell renal cell carcinoma (CCRCC)

Author

Charles H. Lawrie, José I. López, Rosa Guarch, and Jesus M. Cortes

Subjects
Oncology, 0301 basic medicine, medicine.medical_specialty, tumor sampling, Methods for Diagnostic & Therapeutic Studies, clear cell renal cell carcinoma, General Biochemistry, Genetics and Molecular Biology, Cancer Therapeutics, 03 medical and health sciences, Study Protocol, Text mining, 0302 clinical medicine, Intratumor heterogeneity, Internal medicine, medicine, Routine clinical practice, General Pharmacology, Toxicology and Pharmaceutics, General Immunology and Microbiology, multi-site tumor sampling grade, business.industry, Multi site, Sampling (statistics), General Medicine, Articles, Plant biology, medicine.disease, Clear cell renal cell carcinoma, 030104 developmental biology, 030220 oncology & carcinogenesis, Immunology, pathology, business
Abstract

Current standard-of-care tumor sampling protocols for CCRCC (and other cancers) are not efficient at detecting intratumoural heterogeneity (ITH). We have demonstrated in silico that an alternative protocol, multi-site tumor sampling (MSTS) based upon the divide and conquer (DAC) algorithm, can significantly increase the efficiency of ITH detection without extra costs. Now we test this protocol on routine hematoxylin-eosin (HE) sections in a series of 38 CCRCC cases. MSTS was found to outperform traditional sampling when detecting either high grade (p=0.0136) or granular/eosinophilic cells (p=0.0114). We therefore propose that MSTS should be used in routine clinical practice.

Published
2016

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