1. The role of cDC1s in vivo: CD8 T cell priming through cross-presentation
- Author
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Kenneth M. Murphy and Derek J. Theisen
- Subjects
0301 basic medicine ,General Immunology and Microbiology ,biology ,Antigen processing ,business.industry ,Monocyte ,Cross-presentation ,Priming (immunology) ,General Medicine ,Dendritic cell ,Major histocompatibility complex ,General Biochemistry, Genetics and Molecular Biology ,In vitro ,03 medical and health sciences ,030104 developmental biology ,medicine.anatomical_structure ,biology.protein ,medicine ,Cytotoxic T cell ,General Pharmacology, Toxicology and Pharmaceutics ,business ,Neuroscience - Abstract
The cDC1 subset of classical dendritic cells is specialized for priming CD8 T cell responses through the process of cross-presentation. The molecular mechanisms of cross-presentation remain incompletely understood because of limited biochemical analysis of rare cDC1 cells, difficulty in their genetic manipulation, and reliance onin vitrosystems based on monocyte- and bone-marrow-derived dendritic cells. This review will discuss cross-presentation from the perspective of studies with monocyte- or bone-marrow-derived dendritic cells while highlighting the need for future work examining cDC1 cells. We then discuss the role of cDC1s as a cellular platform to combine antigen processing for class I and class II MHC presentation to allow the integration of “help” from CD4 T cells during priming of CD8 T cell responses.
- Published
- 2017
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