1. Improvement in corneal scarring following bacterial keratitis
- Author
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McClintic, SM, Srinivasan, M, Mascarenhas, J, Greninger, DA, Acharya, NR, Lietman, TM, and Keenan, JD
- Subjects
Biomedical and Clinical Sciences ,Ophthalmology and Optometry ,Clinical Trials and Supportive Activities ,Clinical Research ,Physical Injury - Accidents and Adverse Effects ,Eye Disease and Disorders of Vision ,6.1 Pharmaceuticals ,Evaluation of treatments and therapeutic interventions ,Eye ,Adult ,Aged ,Aza Compounds ,Cicatrix ,Corneal Ulcer ,Eye Infections ,Bacterial ,Female ,Fluoroquinolones ,Humans ,Male ,Middle Aged ,Moxifloxacin ,Ophthalmic Solutions ,Pneumococcal Infections ,Prednisolone ,Pseudomonas Infections ,Quinolines ,Vision Disorders ,Visual Acuity ,corneal ulcer ,corneal scar ,SCUT ,Clinical Sciences ,Immunology ,Opthalmology and Optometry ,Ophthalmology & Optometry ,Ophthalmology and optometry - Abstract
AimBacterial keratitis results in corneal scarring and subsequent visual impairment. The long-term evolution of corneal scars has not been well described. In this case series, we identified patients who had improvement in corneal scarring and visual acuity from a clinical trial for bacterial keratitis.MethodsWe searched the records of the Steroids for Corneal Ulcers Trial (SCUT) for patients who had improvement in vision between the 3-month and 12-month visits and reviewed their clinical photographs.ResultsOf the 500 patients enrolled in SCUT, five patients with large central corneal scars due to bacterial keratitis are presented. All experienced improvement in rigid contact lens-corrected visual acuity from months 3 to 12. All patients also had marked improvement in corneal opacity during the same time period. None of the patients opted to have penetrating keratoplasty.ConclusionsCorneal scars may continue to improve even many months after a bacterial corneal ulcer has healed. The corneal remodeling can be accompanied by considerable improvement in visual acuity, such that corneal transplantation may not be necessary.
- Published
- 2013