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Introduction: Electrospinning is a facile and viable method for the fabrication of nanofibers. Electrospun nanofiber has a great potential in providing local drug or therapeutic molecule delivery to the wound site. The versatile nature of this technique ensures a broad scope of material used in the fabrication of nanofibers., Area Covered: A brief introduction to diabetic foot ulcer (DFU) is covered with its pathogenesis, followed by the role of electrospun nanofibers in DFU. This review covers the evolution of the electrospinning technique over the past few years, various types of electrospun nanofibers reported for DFU or chronic diabetic wounds, the challenges associated with the preparation of nanofibers, and various methods to evaluate their efficacy and performance in diabetic wound healing., Expert Opinion: Electrospinning-based nanofibers provide a safe, effective, and multifunctional system for effective management of DFU.