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Your search keyword '"Scola , L."' showing total 3 results
Start Over Author "Scola , L." Journal experimental gerontology
3 results on '"Scola , L."'

2. Analysis of HLA-DRB1,DQA1,DQB1 haplotypes in Sardinian centenarians

Author

Domenico Lio, Luigi Ferrucci, Luca Deiana, Mario G. Pes, Giuseppina Colonna-Romano, Letizia Scola, Giusi Irma Forte, Giovannella Baggio, Giuseppina Candore, Ciriaco Carru, Crivello A, Calogero Caruso, Claudio Franceschi, Istituto Nazionale di Riposo e Cura per Anziani di Ancona and Florence, Istituto Nazionale di Riposo e Cura per Anziani di Ancona, Human Computer Technology Laboratory (HCTLab), Universidad Autonoma de Madrid (UAM), Dipartimento di Patologia Sperimentale, Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), SCOLA L, LIO D, CANDORE G, FORTE GI, CRIVELLO A, COLONNA-ROMANO G, PES MG, CARRU C, FERRUCCI L, DEIANA L, BAGGIO G, FRANCESCHI C, CARUSO C, Scola L., Lio D., Candore G., Forte G.I., Crivello A., Colonna-Romano G., Pes M.G., Carru C., Ferrucci L., Deiana L., Baggio G., Franceschi C., and Caruso C.

Subjects
musculoskeletal diseases, Aging, Linkage disequilibrium, media_common.quotation_subject, Genes, MHC Class II, Longevity, Population, Biology, Biochemistry, Article, HLA-DQ alpha-Chains, Linkage Disequilibrium, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Gene Frequency, HLA-DQ Antigens, Genetics, HLA-DQ beta-Chains, Humans, skin and connective tissue diseases, education, Molecular Biology, HLA-DRB1, Allele frequency, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, Genetic association, media_common, Aged, 80 and over, Likelihood Functions, 0303 health sciences, education.field_of_study, Polymorphism, Genetic, HLA-DQB1, Haplotype, HLA-DR Antigens, Cell Biology, Haplotypes, Italy, HLA, Longevity, Sardinia, Medicine, HLA-DRB1 Chains, 030215 immunology
Abstract

Some genetic determinants of longevity might reside in those polymorphisms for the immune system genes that regulate immune responses. Many longevity association studies focused their attention on HLA (the human MHC) polymorphisms, but discordant results have been obtained. Sardinians are a relatively isolate population and represent a suitable population for association studies. Some HLA-DR and DQ alleles form very stable haplotypes with a strong linkage disequilibrium. In a previous study on Sardinian centenarians we have suggested that HLA-DRB1 *15 allele might be marginally associated to longevity. HLA-DR,DQ haplotypes are in strong linkage disequilibrium and well conserved playing a role in the association to diseases. Hence, we have evaluated, by amplification refractory mutation system/polymerase chain reaction (ARMS-PCR) the HLADQA1 and HLA-DQB1 allele frequencies in 123 centenarians and 92 controls from Sardinia to assess whether the association to HLA-DRB1 *15 allele may be due to the other genes involved in the HLA-DR,DQ haplotypes. The frequencies of HLA-DQA1, DQB1 haplotypes were not significantly modified in centenarians. Nevertheless by evaluating the frequency of DRB1 *15 linked haplotypes, we observed a not significant increase in centenarians of HLA-DQA1 *01, DQB1 *05 and HLA-DQA1 *01,DQB1 *06 haplotypes. These data suggest that these haplotypes might have a role in determining life span expectancy and longevity.

Published
2008
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3. Allele frequencies of +874T-->A single nucleotide polymorphism at the first intron of interferon-gamma gene in a group of Italian centenarians.

Author

Lio D, Scola L, Crivello A, Bonafè M, Franceschi C, Olivieri F, Colonna-Romano G, Candore G, and Caruso C

Subjects
Adult, Aged, Aged, 80 and over, Female, Gene Frequency, Humans, Italy, Male, Middle Aged, Aging genetics, Alleles, Interferon-gamma genetics, Introns, Polymorphism, Single Nucleotide
Abstract

Ageing is characterized by a pro-inflammatory status which could contribute to the onset of major age-related diseases such as cardiovascular diseases, neurodegeneration, osteoarthritis and osteoporosis, and diabetes. Thus, it can be hypothesized that genetic variations in pro- or anti-inflammatory cytokines might influence successful ageing and longevity. We have studied the distribution of +874T-->A interferon-gamma (IFN-gamma) polymorphisms in a large number of Italian centenarians to evaluate if the two alleles might be differently represented in people selected for longevity. DNA samples were obtained from 174 Italian centenarians (>99 years old, 142 women and 32 men) and from 248 <60-year-old control subjects (90 women and 158 men) matched for geographical distribution. Polymorphisms at +874 were identified by using amplification refractory mutational system methodology. The +874T allele was found less frequently in centenarian women than in centenarian men or in control women whereas no significant differences were observed in the distribution of the two alleles between male or female controls. Allele frequencies in centenarian men were not found significantly different from male controls. Possession of the +874A allele, known to be associated with low IFN-gamma production, significantly increases the possibility to achieve extended longevity, suggesting that the pro-inflammatory status characteristic of ageing may be detrimental for successful ageing. The datum that the allele was significantly increased in female but not male centenarians seems to strengthen the idea that gender may be a major variable in the biology of the ageing process. However, the present data add another piece of evidence to the complex puzzle of genetic and environmental factors involved in controlling life span expectancy in humans. Thus, studies on cytokine gene polymorphisms may promise to individuate a complex network of trans-interactive genes able to influence the type and strength of responses to environmental stressors and as a final result, thereby conditioning individual life expectancy.

Published
2002
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