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Start Over Author "Jinlu Dai" Journal experimental gerontology
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2. In vivo visualization of aging-associated gene transcription: evidence for free radical theory of aging

Author

Jinlu Dai, Weici Qi, Stavros C. Manolagas, Zhi Yao, Yi Lu, Charles A O'Brien, Daniel E. Hall, William B. Ershler, Jill M. Murtha, Evan T. Keller, and Jian Zhang

Subjects
Aging, Transcription, Genetic, Transgene, Gene Expression, Mitosis, Endogeny, Mice, Transgenic, Biology, Biochemistry, Mice, Endocrinology, Gene expression, Genetics, Bioluminescence imaging, Animals, RNA, Messenger, Interleukin 6, Muscle, Skeletal, Molecular Biology, Free-radical theory of aging, chemistry.chemical_classification, Reactive oxygen species, Interleukin-6, Reverse Transcriptase Polymerase Chain Reaction, Tumor Necrosis Factor-alpha, NF-kappa B, Cell Biology, Free Radical Scavengers, Molecular biology, Cell biology, Acetylcysteine, Mice, Inbred C57BL, chemistry, Second messenger system, biology.protein, Reactive Oxygen Species
Abstract

The expression of a variety of proteins is elevated with aging through unknown mechanisms. The free radical theory of aging promulgates that reactive oxygen species (ROS) promote the aging process. However, the mechanisms as to how ROS contribute to the aging process are not clear. We present data here that demonstrate that aging induced ROS promote aging-associated interleukin-6 (IL-6) gene transcription in mice that are transgenic for the murine IL-6 promoter driving a luciferase reporter cDNA. N-acetylcysteine (NAC), an antioxidant, completely reverses the increased endogenous IL-6 promoter activity in the old mice determined by real-time bioluminescence imaging (BLI). We conclude that ability of ROS to act as secondary messengers and induce gene expression may contribute to the aging process.

Published
2003

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