1. Mohs micrographic surgery in dermatofibrosarcoma protuberans: Rate and risk factors for recurrence in a prospective cohort study from the Spanish Registry of Mohs Surgery (REGESMOHS) and review of the literature
- Author
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Lucia Carnero-González, Alberto Alfaro Rubio, Veronica Ruiz-Salas, Izascun Ocerin-Guerra, J.R. Garcés, Pedro Redondo, Natividad Cano-Martinez, Miguel Ángel Descalzo, Eva Vilarrasa, Julia M Sánchez-Schmidt, Victoriano Morales-Gordillo, O. Sanmartín-Jiménez, Ignacio García-Doval, Antonio Martorell Calatayud, Beatriz García-Bracamonte, Rafael Botella-Estrada, A. Toll-Abelló, Begoña Escutia-Muñoz, José L. López-Estebaranz, C García-Donoso, Lula María Nieto-Benito, R. Miñano-Medrano, Pilar Gil, Regesmohs, Yolanda Delgado-Jiménez, Laura Sainz-Gaspar, Pablo de la Cueva Dobao, Pedro Sánchez-Sambucety, Raquel Navarro-Tejedor, Lucía Barchino-Ortiz, Hugo Vázquez-Veiga, Juan L Artola-Igarza, Cristina Ciudad-Blanco, Irati Allende-Markixana, Esther de Eusebio-Murillo, Manuel Ángel Rodríguez-Prieto, B. González-Sixto, Ricardo Suárez-Fernández, Carlos Feal-Cortizas, María L Alonso-Pacheco, and Matías Mayor-Arenal
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Skin Neoplasms ,Demographics ,medicine.medical_treatment ,Dermatologic Surgical Procedures ,Dermatology ,Biochemistry ,Micrographic surgery ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Neoplasm Recurrence ,Risk Factors ,Epidemiology ,Dermatofibrosarcoma protuberans ,medicine ,Mohs surgery ,Humans ,Neoplasm Invasiveness ,Prospective Studies ,Registries ,Prospective cohort study ,Molecular Biology ,business.industry ,organic chemicals ,fungi ,Dermatofibrosarcoma ,medicine.disease ,Mohs Surgery ,Surgery ,030104 developmental biology ,business - Abstract
Characterization of patients, surgery procedures and the risk factors for dermatofibrosarcoma protuberans (DFSP) recurrences is poorly defined. In this study, we aimed to describe the demographics, tumor characteristics and interventions of DFSP treated with Mohs micrographic surgery (MSS) to determine the rate and risk factors for recurrence. Data were collected from REGESMOHS, a nationwide prospective cohort study of patients treated with MMS in Spain. From July 2013 to February 2020, 163 patients with DFSP who underwent MMS were included. DFSP was mostly located on trunk and extremities. Recurrent tumors had deeper tumor invasion and required higher number of MMS stages. Paraffin MMS was the most frequently used technique. Overall recurrence rate was 0.97 cases/100 person-years (95% IC = 0.36-2.57). No differences were found in epidemiological, tumor, surgery characteristics or surgical technique (frozen or paraffin MMS [p = 0.6641]) in terms of recurrence. Median follow-up time was 28.6 months with 414 patient-years of follow-up. In conclusion, we found an overall low recurrence rate of DFSP treated with MMS. None of the studied risk factors, including MMS techniques, was associated with higher risk for recurrence.
- Published
- 2021