1. Psoriasis: characterization of six different clinical phenotypes
- Author
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Marc Perrussel, Nejib Doss, Julie Latreille, Christiane Guinot, Louis Dubertret, CENTRE DE RECHERCHES ET D'INVESTIGATIONS EPIDERMIQUES ET SENSORIELLES (CERIES), CERIES, Université de Tours (UT), Centre d'enseignement Cnam Paris (CNAM Paris), Conservatoire National des Arts et Métiers [CNAM] (CNAM), Department of Dermatology, Military Hospital of Tunis, Service de dermatologie [Paris], Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université de Tours, and Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)
- Subjects
Adult ,Male ,medicine.medical_specialty ,Multivariate analysis ,[SDV]Life Sciences [q-bio] ,Dermatology ,Bioinformatics ,Biochemistry ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Psoriasis ,Surveys and Questionnaires ,Medicine ,Cluster Analysis ,Humans ,Prospective Studies ,Age of Onset ,Clinical phenotype ,Prospective cohort study ,Molecular Biology ,Disease entity ,Models, Genetic ,business.industry ,Middle Aged ,medicine.disease ,Phenotype ,3. Good health ,030220 oncology & carcinogenesis ,Multivariate Analysis ,Female ,Age of onset ,business - Abstract
International audience; Until recently, psoriasis was considered as a single disease entity. However, the discovery of major differences between early- or late-onset psoriasis suggests the presence of distinct disease phenotypes which may differ in their pathophysiology and in their treatment responsiveness. The objective of this study was to use exploratory data analysis methods to identify potential clinical psoriasis phenotypes without a priori hypotheses. A prospective questionnaire-based survey collected comprehensive informations on the main clinical characteristics of 1484 psoriatic patients. Six statistically different clusters of clinical symptoms were observed, corresponding at least to six different clinical psoriasis phenotypes. Moreover, discriminant functions allow patients to be assigned to one or other of these phenotypes. Our findings open the way to focus genetic, pharmaco-genetic, pathophysiological and therapeutic studies on more homogenous group of patients.
- Published
- 2009
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