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Your search keyword '"Vidhya, V."' showing total 3 results
Start Over Author "Vidhya, V." Journal experimental cell research
3 results on '"Vidhya, V."'

2. CCAAT/enhancer-binding protein-β has a role in osteoblast proliferation and differentiation

Author

Laura R. McCabe, Richard C. Schwartz, Vidhya V. Iyer, and Tejas B. Kadakia

Subjects
Osteocalcin, Regulator, 3T3 cells, Mice, Enhancer binding, medicine, Animals, Insulin-Like Growth Factor I, Gene, Regulation of gene expression, Osteoblasts, biology, Ccaat-enhancer-binding proteins, Interleukin-6, CCAAT-Enhancer-Binding Protein-beta, Cell Differentiation, Osteoblast, 3T3 Cells, Cell Biology, Molecular biology, DNA-Binding Proteins, medicine.anatomical_structure, Animals, Newborn, Gene Expression Regulation, biology.protein, biological phenomena, cell phenomena, and immunity, Cell Division, hormones, hormone substitutes, and hormone antagonists
Abstract

CCAAT/enhancer binding protein beta (C/EBPbeta) is known to play an important role in the expression of several genes necessary for bone development and homeostasis including osteocalcin, IGF-1, and IL-6. In this study, we show that C/EBPbeta protein levels and, consequently, DNA-binding activity are temporally regulated, dramatically decreasing upon differentiation of MC3T3-E1 mouse osteoblasts. Corresponding with these results, the constitutive expression of C/EBPbeta LAP in MC3T3-E1 osteoblasts increased proliferation and suppressed osteogenic differentiation. Thus, C/EBPbeta LAP not only appears to participate in the regulation of genes associated with mature bone physiology, but is also a critical regulator of osteoblast growth and differentiation.

Published
2004

3. CCAAT/enhancer-binding protein-beta has a role in osteoblast proliferation and differentiation.

Author

Iyer VV, Kadakia TB, McCabe LR, and Schwartz RC

Subjects
3T3 Cells, Animals, Animals, Newborn, CCAAT-Enhancer-Binding Protein-beta genetics, DNA-Binding Proteins metabolism, Gene Expression Regulation, Insulin-Like Growth Factor I genetics, Interleukin-6 genetics, Mice, Osteocalcin genetics, CCAAT-Enhancer-Binding Protein-beta physiology, Cell Differentiation physiology, Cell Division physiology, Osteoblasts cytology
Abstract

CCAAT/enhancer binding protein beta (C/EBPbeta) is known to play an important role in the expression of several genes necessary for bone development and homeostasis including osteocalcin, IGF-1, and IL-6. In this study, we show that C/EBPbeta protein levels and, consequently, DNA-binding activity are temporally regulated, dramatically decreasing upon differentiation of MC3T3-E1 mouse osteoblasts. Corresponding with these results, the constitutive expression of C/EBPbeta LAP in MC3T3-E1 osteoblasts increased proliferation and suppressed osteogenic differentiation. Thus, C/EBPbeta LAP not only appears to participate in the regulation of genes associated with mature bone physiology, but is also a critical regulator of osteoblast growth and differentiation.

Published
2004
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