1. Behavioural recovery following striatal transplantation: effects of postoperative training and P-zone volume.
- Author
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Brasted PJ, Watts C, Torres EM, Robbins TW, and Dunnett SB
- Subjects
- Animals, Fetal Tissue Transplantation, Functional Laterality, Male, Rats, Reaction Time, Time Factors, Brain Tissue Transplantation physiology, Conditioning, Operant physiology, Corpus Striatum physiology, Corpus Striatum transplantation, Learning physiology
- Abstract
Rats were trained on an operant task and then received striatal lesions and grafts. Grafts were derived either from whole-ganglionic eminences or restricted to the lateral eminence. When retested 4 months later; graft-associated behavioural recovery was only apparent with extensive retesting. There was no difference in performance between rats that received whole-dissection or lateral-dissection grafts, and no correlation between performance and the amount of striatal-like (P-zone) tissue within the graft. It is suggested that P-zone reconstruction may be necessary, but not sufficient for behavioural recovery, which may additionally depend upon rehabilitative training.
- Published
- 1999
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