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In studying the nerve pathways involved in the reflex inhibition of hunger contractions by distention of a Thiry fistula loop in the dog,1 it was noticed that a previous long-continued distention of the loop brought about a lower threshold for the reflex.In the experiments here reported, five animals were prepared with Thiry fistulae in the usual manner, the loops being 15-20 cm. long and taken from the upper ileum. After complete recovery the dogs were trained to swallow a stomach tube and to lie quietly on the table without any restraint. Gastric movements were recorded by the customary balloon-tambour method. The intestinal loops were distended by air inflation of a thin-walled balloon which was over-size relative to the lumen of the gut. The balloon was tied over a glass rod so that the expansion would be entirely lateral and the pressure readings would closely approximate the pressure actually applied to the intestinal wall. All records were made after a fasting period of 18-24 hours. In testing for ...

SummaryAcid in upper small intestine causes immediate inhibition of gastric motility. Sixteen dogs were prepared with gastric fistula and/or Heidenhain pouch plus a Maydl fistula of upper jejunum. ...

Numerous investigators have reported a delay in gastric evacuation as a result of placing acid, fat, gastric juice, etc., in the duodenum or other parts of the small intestine. The effect has generally been attributed to a reflex (the “Hirsch v. Mering reflex”) causing tonic contraction of the pyloric sphincter. However, two studies record inhibition of contractions of the pars pylorica following the introduction of acid1 or fat2 into the duodenum. Apparently both investigations were made upon the empty stomach, though Edelmann2 observed inhibition of gastric contractions during secretion of gastric juice. There are no data in either report to prove that the phenomenon occurs in the full stomach or has any bearing on the mechanism of gastric evacuation.We studied the effect of placing various substances in the duodenum while recording graphically the tone changes in the pyloric sphincter by means of the pressure tonometer,3 and the contractions of the pars pylorica by means of a balloon placed in the pylo...