1. Inhibition of lipid peroxidation by diterpenoid from Podocarpus nagi.
- Author
-
Haraguchi H, Ishikawa H, Sakai S, Ying BP, and Kubo I
- Subjects
- Abietanes, Adenosine Diphosphate analogs & derivatives, Adenosine Diphosphate pharmacology, Animals, Erythrocyte Membrane metabolism, Humans, Linoleic Acid, Linoleic Acids metabolism, Male, Membrane Lipids blood, Microsomes, Liver drug effects, Microsomes, Liver metabolism, Mitochondria, Liver drug effects, Mitochondria, Liver metabolism, NAD metabolism, NAD pharmacology, NADP metabolism, NADP pharmacology, Oxidation-Reduction, Rats, Rats, Wistar, Antioxidants pharmacology, Diterpenes pharmacology, Lipid Peroxidation drug effects
- Abstract
A diterpenoid, totarol (1), from Podocarpus nagi was evaluated as an antioxidant. This diterpenoid inhibited autoxidation of linoleic acid. Mitochondrial and microsomal lipid peroxidation induced by Fe(III)-ADP/NADH or Fe(III)-ADP/NADPH were also inhibited. Nagilactone E (2), a norditerpene lactone isolated from the same source, had no antioxidative activity. Furthermore, totarol protected red cells against oxidative hemolysis. This diterpene was shown to be effective in protecting biological systems against oxidative stresses.
- Published
- 1996
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