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The binding ofH-spiroperidol to striatal membranes from a strain of mutant Han-Wistar rats was compared with that in normal littermate animals. The specific binding was less in the mutants than the controls. Scatchard analysis revealed that the K- and B-values for the high affinity binding sites in the mutants are greater than for those in the controls. These findings indicate that the dopamine receptors of the mutants are affected and could explain some of the previous data; it has been suggested that some of the spasticity observed in the mutants may be due to an abnormal functioning of their dopaminergic neurones. [ABSTRACT FROM AUTHOR]

The distribution and characterization of MAO in various tissues of the snail were analyzed. Only low amounts of the enzyme exist in the different tissues and data suggest that there is more than one type of MAO. [ABSTRACT FROM AUTHOR]