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Occupational stress occurs in the working environment where the stressors may be physical, chemical, biologic or psychosocial in nature. This review especially emphasizes the most novel and probably most prevalent type of work-related factors and response to them: psychologic stress. A brief historical introduction concerning the development of the (biologic) stress concept underlines the duality of stressors (i.e., extremely unpleasant and pleasant events, too much work and work stagnation) equally cause stress. A section on 'Recognition and manifestation' emphasizes the need for understanding the origins and nature of occupational stress before considering its manifestations (e.g., nonspecific behavioral changes and specific hormone level measurements). Under 'Prevention and treatment' reduction or avoidance of psychosocial stressors coupled with minimizing predisposing and promoting protective intervening variables are discussed. Thus, although occupational stress might be a major complication at the workplace, understanding this stress could lead to its partial or complete prevention.