1. Partialsynthese des Aldosterons
- Author
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K. Heusler, G. Cainelli, D. Arigoni, O. Jeger, J. Kalvoda, Albert Wettstein, P. Wieland, Ch. Meystre, and Georg Anner
- Subjects
Pharmacology ,Cellular and Molecular Neuroscience ,chemistry.chemical_compound ,Aldosterone ,Biochemistry ,chemistry ,Stereochemistry ,Molecular Medicine ,Cell Biology ,Molecular Biology ,Hormone - Abstract
The preparation of the (18 → 11β)-lactone ofΔ5-3-ethylenedioxy-11β-hydroxy-21-acetoxy-20-oxo-pregnen-18-oic acid (XV) is reported. Since this compound has previously been transformed into aldosterone, the reactions described represent the first partial synthesis of this important hormone from readily available 18-unsubstituted natural steroids.
- Published
- 1960