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Start Over Descriptor "evolutionary mismatch" Journal evolutionary applications
3 results on '"evolutionary mismatch"'

1. Rare and unique adaptations to cancer in domesticated species: An untapped resource?

Author

Frédéric Thomas, Mathieu Giraudeau, Nolwenn M. Dheilly, Flora Gouzerh, Justine Boutry, Christa Beckmann, Peter A. Biro, Rodrigo Hamede, Jerome Abadie, Sophie Labrut, Margaux Bieuville, Dorothée Misse, Georgina Bramwell, Aaron Schultz, Guillaume Le Loc'h, Orsolya Vincze, Benjamin Roche, François Renaud, Tracey Russell, and Beata Ujvari

Subjects
cancer, domestication, domestication syndrome, evolution, evolutionary mismatch, selection, Evolution, QH359-425
Abstract

Abstract Strong and ongoing artificial selection in domestic animals has resulted in amazing phenotypic responses that benefit humans, but often at a cost to an animal's health, and problems related to inbreeding depression, including a higher incidence of cancer. Despite high rates of cancer in domesticated species, little attention has been devoted to exploring the hypothesis that persistent artificial selection may also favour the evolution of compensatory anticancer defences. Indeed, there is evidence for effective anti‐cancer defences found in several domesticated species associated with different cancer types. We also suggest that artificial selection can favour the “domestication” of inherited oncogenic mutations in rare instances, retaining those associated to late and/or less aggressive cancers, and that by studying these seemingly rare anticancer adaptations, novel cancer treatments may be found.

Published
2020
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2. Rare and unique adaptations to cancer in domesticated species: An untapped resource?

Author

Thomas, Frédéric, Giraudeau, Mathieu, Dheilly, Nolwenn M., Gouzerh, Flora, Boutry, Justine, Beckmann, Christa, Biro, Peter A., Hamede, Rodrigo, Abadie, Jerome, Labrut, Sophie, Bieuville, Margaux, Misse, Dorothée, Bramwell, Georgina, Schultz, Aaron, Le Loc'h, Guillaume, Vincze, Orsolya, Roche, Benjamin, Renaud, François, Russell, Tracey, and Ujvari, Beata

Subjects
*ARTIFICIAL selection of animals, *BREEDING, *CANCER
Abstract

Strong and ongoing artificial selection in domestic animals has resulted in amazing phenotypic responses that benefit humans, but often at a cost to an animal's health, and problems related to inbreeding depression, including a higher incidence of cancer. Despite high rates of cancer in domesticated species, little attention has been devoted to exploring the hypothesis that persistent artificial selection may also favour the evolution of compensatory anticancer defences. Indeed, there is evidence for effective anti‐cancer defences found in several domesticated species associated with different cancer types. We also suggest that artificial selection can favour the "domestication" of inherited oncogenic mutations in rare instances, retaining those associated to late and/or less aggressive cancers, and that by studying these seemingly rare anticancer adaptations, novel cancer treatments may be found. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

3. Rare and unique adaptations to cancer in domesticated species: An untapped resource?

Author

Dorothée Missé, Georgina Bramwell, Aaron G. Schultz, Margaux Bieuville, Beata Ujvari, Nolwenn M. Dheilly, Jérôme Abadie, Péter Biró, Sophie Labrut, Tracey Russell, Flora Gouzerh, Justine Boutry, François Renaud, Orsolya Vincze, Rodrigo Hamede, Guillaume Le Loc'h, Mathieu Giraudeau, Benjamin Roche, Frédéric Thomas, Christa Beckmann, Centre de Recherches Ecologiques et Evolutives sur le Cancer (CREEC), Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Interactions hôtes-agents pathogènes [Toulouse] (IHAP), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Unité de modélisation mathématique et informatique des systèmes complexes [Bondy] (UMMISCO), Institut de la francophonie pour l'informatique-Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Université Gaston Bergé (Saint-Louis, Sénégal)-Universtié Yaoundé 1 [Cameroun]-Université Cadi Ayyad [Marrakech] (UCA)-Sorbonne Université (SU)-Institut de Recherche pour le Développement (IRD [France-Nord]), Centre de Recherches Ecologiques et Evolutives sur le Cancer (MIVEGEC-CREEC), Processus Écologiques et Évolutifs au sein des Communautés (PEEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), School of Marine and Atmospheric Sciences [Stony Brook] (SoMAS), Stony Brook University [SUNY] (SBU), State University of New York (SUNY)-State University of New York (SUNY), Deakin University, Burwood, Australia, Deakin University [Burwood], Western Sydney University, University of Tasmania [Hobart, Australia] (UTAS), Animaux modèles pour la recherche en oncologie comparée (AMaROC), Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS), Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Hungarian Department of Biology and Ecology [Cluj‑Napoca, Romania], Babes-Bolyai University [Cluj-Napoca] (UBB), MTA Centre for Ecological Research [Tihany], Hungarian Academy of Sciences (MTA), Institut de Recherche pour le Développement (IRD [France-Nord])-Institut de la francophonie pour l'informatique-Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Université Gaston Bergé (Saint-Louis, Sénégal)-Université Cadi Ayyad [Marrakech] (UCA)-Université de Yaoundé I-Sorbonne Université (SU), The University of Sydney, This work was supported by an ARC Linkage (LP170101105), Deakin SEBE_RGS_2019, an ANR TRANSCAN (ANR-18-CE35-0009) and a CNRS 'International Associated Laboratory Grant.' Support was also provided by the Rotary Club Les Sables d’Olonne to FT. OV is supported by the Romanian Ministry of Research and Innovation (PN-III-P4-ID-PCE-2016-0404), by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences and by the New National Excellence Program of the Ministry of Innovation and Technology (ÚNKP-19-4-DE-538)., ANR-18-CE35-0009,TRANSCAN,ECOLOGIE ET EVOLUTION DES CANCERS TRANSMISSIBLES(2018), École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Université de Yaoundé I-Institut de la francophonie pour l'informatique-Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Université Gaston Bergé (Saint-Louis, Sénégal)-Université Cadi Ayyad [Marrakech] (UCA)-Sorbonne Université (SU)-Institut de Recherche pour le Développement (IRD [France-Nord])

Subjects
0106 biological sciences, 0301 basic medicine, evolutionary mismatch, Resource (biology), [SDV]Life Sciences [q-bio], domestication syndrome, lcsh:Evolution, selection, Biology, 010603 evolutionary biology, 01 natural sciences, 03 medical and health sciences, domestication, evolutionary, evolution, Genetics, Inbreeding depression, medicine, lcsh:QH359-425, cancer, Domestication, Ecology, Evolution, Behavior and Systematics, Selection (genetic algorithm), High rate, Cancer, Mismatch theory, medicine.disease, 030104 developmental biology, Evolutionary biology, General Agricultural and Biological Sciences, mismatch
Abstract

International audience; Strong and ongoing artificial selection in domestic animals has resulted in amazing phenotypic responses that benefit humans, but often at a cost to an animal's health, and problems related to inbreeding depression, including a higher incidence of cancer. Despite high rates of cancer in domesticated species, little attention has been devoted to exploring the hypothesis that persistent artificial selection may also favour the evolution of compensatory anticancer defences. Indeed, there is evidence for effective anti‐cancer defences found in several domesticated species associated with different cancer types. We also suggest that artificial selection can favour the “domestication” of inherited oncogenic mutations in rare instances, retaining those associated to late and/or less aggressive cancers, and that by studying these seemingly rare anticancer adaptations, novel cancer treatments may be found.

Published
2020

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