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Examines the geographic pattern of genetically determined resistance in the garter snake Thamnopis sirtalis over much of its ecological interaction with toxic newts of genus Taricha. Importance of geographic structure to coevolutionary interactions between predators and prey; Predictions of the geographic mosaic process; Evidence which suggests that selection is essential in determining population variation in resistance.

Presents a study which investigated whether resistance to the neurotoxin of a prey and locomotor performance were negatively associated in a species of garter snakes. Genetic basis of the trade-off; Methodology of the study; Results and discussions.