1. Anti-Inflammatory Activity of the Essential Oil Citral in Experimental Infection with Staphylococcus aureus in a Model Air Pouch
- Author
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Suzi P. de Carvalho, Hellen Braga Martins, Lucas Miranda Marques, Regiane Yatsuda, Lorena D'Oliveira Gusmão, Ana Paula Trovatti Uetanabaro, Anne Karoline Pereira Brito, Flávia S. Nascimento, Samira Itana de Souza, Jannine Dos Santos Nascimento, Nathan das Neves Selis, Clarissa Leal Silva e Souza, Márcio Vasconcelos Oliveira, and Jorge Timenetsky
- Subjects
0301 basic medicine ,Article Subject ,medicine.drug_class ,Antibiotics ,Biology ,medicine.disease_cause ,Citral ,Anti-inflammatory ,Microbiology ,law.invention ,03 medical and health sciences ,chemistry.chemical_compound ,law ,Gene expression ,medicine ,Essential oil ,EXPRESSÃO GÊNICA ,lcsh:Other systems of medicine ,Antimicrobial ,lcsh:RZ201-999 ,030104 developmental biology ,Complementary and alternative medicine ,chemistry ,Staphylococcus aureus ,Tumor necrosis factor alpha ,Research Article - Abstract
This study proposes to implement an alternative and effective strategy for local treatment of disease provoked byS. aureus. For the analysis of possible anti-inflammatory activity of essential oil, after establishing an air pouch model, 48 male mice of Balb/c were treated, infected, and euthanized at 4 and 8 h. Thus, the total and differential white blood cells were counted in the animal’s blood, and cytokines IL-1β, IL-6, and TNF-αwere titrated using ELISA in the air pouch lavage. Moreover, TNF-α, IL-1β, and IL-6 gene expression was analyzed through an RT-qPCR array, andS. aureuswas quantified using qPCR. Our results,p<0.05, showed that EOC reduced the quantity of microorganisms. The group of mice treated with essential oil citral showed a significant decrease in TNF-αlevels in tests demonstrating anti-inflammatory activity. There is no data about the mutual influence of the air pouch model, essential oil citral, andS. aureus. Thus, considering the interaction of these variables and the anti-inflammatory activity of the essential oil citral, we demonstrated, by alternative local treatment, a new antimicrobial agent that is not an antibiotic.
- Published
- 2017
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