1. Cytotoxic and Antimigratory Activities of Phenolic Compounds from Dendrobium brymerianum.
- Author
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Pornprom Klongkumnuankarn, Kesarin Busaranon, Pithi Chanvorachote, Boonchoo Sritularak, Vichien Jongbunprasert, and Kittisak Likhitwitayawuid
- Subjects
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LUNG tumors , *PHENOL analysis , *MEDICINAL plants , *ALTERNATIVE medicine , *ANALYSIS of variance , *ANTINEOPLASTIC agents , *BIOLOGICAL assay , *BIOLOGICAL models , *PHYSICAL & theoretical chemistry , *DOSE-effect relationship in pharmacology , *LIQUID chromatography , *PROBABILITY theory , *RESEARCH funding , *STATISTICS , *PLANT extracts , *DATA analysis , *DATA analysis software , *CELL migration inhibition , *DESCRIPTIVE statistics , *IN vitro studies , *PHARMACODYNAMICS , *PREVENTION - Abstract
Chromatographic separation of a methanol extract prepared from the whole plant of Dendrobium brymerianum led to the isolation of eight phenolic compounds. Among the isolated compounds (1-8), moscatilin (1), gigantol(3),lusianthridin (4), and dendroflorin (6) showed appreciable cytotoxicity against human lung cancer cell lines with IC50 values of 196.7, 23.4, 65.0, and 125.8 µg/mL, respectively, and exhibited antimigratory property at nontoxic concentrations. This study is the first report on the biological activities of this plant. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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