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2 results on '"STATISTICS"'

1. Cytotoxic and Antimigratory Activities of Phenolic Compounds from Dendrobium brymerianum.

Author

Pornprom Klongkumnuankarn, Kesarin Busaranon, Pithi Chanvorachote, Boonchoo Sritularak, Vichien Jongbunprasert, and Kittisak Likhitwitayawuid

Subjects
*LUNG tumors, *PHENOL analysis, *MEDICINAL plants, *ALTERNATIVE medicine, *ANALYSIS of variance, *ANTINEOPLASTIC agents, *BIOLOGICAL assay, *BIOLOGICAL models, *PHYSICAL & theoretical chemistry, *DOSE-effect relationship in pharmacology, *LIQUID chromatography, *PROBABILITY theory, *RESEARCH funding, *STATISTICS, *PLANT extracts, *DATA analysis, *DATA analysis software, *CELL migration inhibition, *DESCRIPTIVE statistics, *IN vitro studies, *PHARMACODYNAMICS, *PREVENTION
Abstract

Chromatographic separation of a methanol extract prepared from the whole plant of Dendrobium brymerianum led to the isolation of eight phenolic compounds. Among the isolated compounds (1-8), moscatilin (1), gigantol(3),lusianthridin (4), and dendroflorin (6) showed appreciable cytotoxicity against human lung cancer cell lines with IC50 values of 196.7, 23.4, 65.0, and 125.8 µg/mL, respectively, and exhibited antimigratory property at nontoxic concentrations. This study is the first report on the biological activities of this plant. [ABSTRACT FROM AUTHOR]

Published
2015
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2. The Combined Extract of Zingiber officinale and Zea mays (Purple Color) Improves Neuropathy, Oxidative Stress, and Axon Density in Streptozotocin Induced Diabetic Rats.

Author

Jintanaporn Wattanathorn, Paphaphat Thiraphatthanavong, Supaporn Muchimapura, Wipawee Thukhammee, Kamol Lertrat, and Bhalang Suriharn

Subjects
*BLOOD sugar analysis, *DIABETIC neuropathies, *ENZYME metabolism, *ALTERNATIVE medicine, *ANIMAL experimentation, *BIOPHYSICS, *COMBINATION drug therapy, *CORN, *DOSE-effect relationship in pharmacology, *GINGER, *HISTOLOGICAL techniques, *HYPOGLYCEMIC agents, *MATHEMATICS, *RESEARCH methodology, *MEDICINAL plants, *NERVE tissue, *NEURAL conduction, *ORAL drug administration, *PROBABILITY theory, *RATS, *RESEARCH funding, *SCIATIC nerve, *SEEDS, *STATISTICS, *SUPEROXIDE dismutase, *MALONDIALDEHYDE, *PLANT extracts, *DATA analysis, *OXIDATIVE stress, *DATA analysis software, *DESCRIPTIVE statistics, *PAIN threshold, *ONE-way analysis of variance, *PHARMACODYNAMICS, *PHYSIOLOGY, *PREVENTION
Abstract

Based on the protective effect of the combined extract of purple waxy corn and ginger (PWCG) on oxidative stress related disorders in diabetic condition, we aimed to determine the effect of PWCG on the functional, biochemical, and structural change of the lesion nerve in streptozotocin- (STZ-) diabetic rats. PWCG at doses of 100, 200, and 300 mg⋅kg-1 BW were orally given to STZ-diabetic rats which were subjected to chronic constriction (CCI) at right sciatic nerve for 21 days. The blood sugar was assessed before and at the end of study whereas the sciatic function index (SFI), paw withdrawal threshold intensity (PWTI), and paw withdrawal latency (PWL) were assessed every 3 days until the end of study At the end of study, the determination of nerve conduction velocity (NCV), axon density, oxidative stress status, and aldose reductase (AR) activity of the lesion nerve were performed. It was found that PWCG improved SFI, PWTI, PWL, and NCV together with the improved oxidative stress status and the axon density in the lesion nerve. No changes of AR activity or blood sugar level were observed. Therefore, PWCG might improve the functional and structural changes in STZ-diabetic rats plus CCI via the improved oxidative stress status. [ABSTRACT FROM AUTHOR]

Published
2015
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