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OBJECTIVE: To investigate the characteristics and regularities of adverse drug reactions (ADR) in Jiangsu Donghai County People’s Hospital (hereinafter referred to as “our hospital”) , so as to provide reference for clinical rational drug application. METHODS: Retrospectively analysis was conducted on 314 cases of ADR reports in terms of types, patients’ genders and ages, ADR-inducing administration routes and drugs, ADR involved organs and (or) systems and its main clinical features, ADR prognoses and the relevance evaluations of ADR. RESULTS: Among the 314 reports of ADR, 171 cases were general ADR (54. 46% ) , 41 cases were severe ADR ( 13. 06% ) , 102 cases were new and severe ADR (32.48%); the number of male patients was slightly more than that of females; most patients aged ≤ 3; most ADR were induced by intravenous drip, the second was oral administration and intravenous injection. 86 kinds of 11 categories of drugs were involved in the 314 reports of ADR, the top 3 ADR-inducing drugs were respectively antibiotics, traditional Chinese medicine and drugs for nervous system; among reports of ADR induced by antibiotics, the top 3 were respectively cephalosporins, macrolides and fluoroquinolones. ADR mainly involved skin and its accessories, the second were digestive system and circulatory system. Of the relevance evaluations, 80 cases were “definitely” (25.48%), 52 cases were “possible” (16.56%), 182 cases were “probably” (57.96%). All patients were cured or went better after treatment. CONCLUSIONS: The occurrence of ADR was related to various factors, ADR reporting and monitoring on medication should be reinforced; clinical pharmacists should lake active participation in clinical treatment to promote rational medication. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To investigate the characteristics and laws of adverse drug reaction (ADR) in People's Hospital of Jiangsu Donghai County (hereinafter referred to as"our hospital"), and to provide reference for the rational drug use in clinic. METHODS: Retrospective analysis was conducted on 202 cases of ADR reports that were reported to China's National Center for ADR Monitoring by our hospital during 2013-2014, in terms of patients' age and gender, categories of ADR-inducing drugs, ADR-involved organs and (or) systems and clinical manifestations. RESULTS: Of the 202 cases, the age span was large, from 1 d ~ 84 years old. Male to female ratio was 1 ∶ 3. 5. And the main administration route was intravenous administration, totally 194 cases (96. 04%); 10 types of drugs were involved, among which 119 cases (58. 91%) were anti-infective drugs, followed by traditional Chinese preparation, totally 43 cases (21. 29%). 97 cases (48. 02%) with skin and its appendages impairment took the lead, followed by 38 cases (18. 81%) with digestive system damage. CONCLUSIONS: It is necessary to strengthen the ADR monitoring and disseminate ADR knowledge, so as to ensure the medication safety in patients. [ABSTRACT FROM AUTHOR]