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OBJECTIVE: To explore the mechanism of Qianghuo Shengshi decoction in the treatment of rheumatoid arthritis (RA) based on network pharmacology and molecular docking. METHODS: After reviewing the literature and exploring the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform, the key active components and target genes of seven traditional Chinese medicines in Qianghuo Shengshi decoction were obtained. RA-related target genes in GeneCards and on-line Mendelian Inheritance in Man database were retrieved. Based on R language, the target gene of Qianghuo Shengshi decoction-RA interaction was obtained. STRING database was used to construct the protein-protein interaction network diagram. R language was used to calculate the degree value of each node to the histogram and obtain the top 5 target proteins of the degree value. Cytoscape 3. 8. 2 software was used to construct the network diagram of interaction between traditional Chinese medicine related components and RA targets. The top 5 active components in terms of degree value were analyzed by using the Analyze Network plug-in. The obtained genes were analyzed for Gene Ontology (GO) functional enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment by using R language and Bioconductor bioinformatics software package. The signal-target pathway network diagram was constructed by using Cytoscape 3. 8. 2 software. Pymol and AutoDockTools software were adopted to process proteins, ligands and small molecules for molecular docking analysis, Vina was used to calculate the binding free energy and generate molecular docking diagrams. RESULTS: A total of 141 active components and 2 497 target genes were screened for Qianghuo Shengshi decoction. A total of 633 RA-related targets were obtained, and 70 common target genes of Qianghuo Shengshi decoction-RA were obtained after removing duplicates, mainly for signal transduction and transcriptional activator 3, JUN, RELA, mitogen activated protein kinase (MAPK) 1 and MAPK14. GO function and KEGG analysis revealed that the main pathways of action were the response to lipopolysaccharides, the response to bacterial derived molecules, the response of cells to chemical stress, the response to oxidative stress, and the regulation of inflammatory responses. Notably, molecular docking analysis indicated a strong binding effect between the active components and target genes. CONCLUSIONS: Qianghuo Shengshi decoction in the treatment of RA is characterized by multi-components, multi-targets and multi-pathways, which provides scientific basis for its clinical application and further experimental research. [ABSTRACT FROM AUTHOR]

Copyright of Evaluation & Analysis of Drug-Use in Hospitals of China is the property of Evaluation & Analysis of Drug-Use in Hospitals of China Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Evaluation & Analysis of Drug-Use in Hospitals of China is the property of Evaluation & Analysis of Drug-Use in Hospitals of China Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Evaluation & Analysis of Drug-Use in Hospitals of China is the property of Evaluation & Analysis of Drug-Use in Hospitals of China Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Evaluation & Analysis of Drug-Use in Hospitals of China is the property of Evaluation & Analysis of Drug-Use in Hospitals of China Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Evaluation & Analysis of Drug-Use in Hospitals of China is the property of Evaluation & Analysis of Drug-Use in Hospitals of China Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

OBJECTIVE: To investigate the application of antibiotics in Traditional Chinese Medicine Hospital of Yangjiang (hereinafter referred to as “our hospital”), so as to provide reference for improvement of rational drug application. METHODS: Excel software was used, statistical analysis was conducted on consumption sum, defined daily dose system (DDDs), defined daily cost (DDC) and B/ A of antibiotics in our hospital during 2015-2017. RESULTS: During 2015-2017, the ratio of consumption sum of antibiotics to the total consumption sum of drugs (12%-14%) met the relevant requirements, and the overall trend was downward. The top 5 categories of antibiotics ranked by ranking of consumption sum and DDDs were respectively cephalosporins, penicillins and fluoroquinolones, among which the ranking of consumption sum and DDDs of cephalosporins took the lead. CONCLUSIONS: The distribution of antibiotics in our hospital and the application of most antibiotics are basically reasonable, in line with the requirements of the Guiding Principles for Clinical Application of Antimicrobial Drugs (2015 Edition). Yet there are still some problems. It is necessary to further strengthen the rational application of antibiotics, optimize the structure and promote the continuous improvement of the clinical application of antibiotics. [ABSTRACT FROM AUTHOR]

OBJECTIVE:To observe the clinical effects of compound anisodine injections combined with vitamin B12 injections in treatment of primary and secondary ischemic optic neuropathy. METHODS： 141 cases (group A) of primary ischemic optic neuropathy and 108 cases ( group B ) of secondary ischemic optic neuropathy admitted into Zhengzhou the Second People’s Hospital from Jan. 2013 to Oct，in order to facilitate，for binocular ION patients，chose one eye with worse vision into the study. 2015 were extracted. Group A were divided into control group A，observation group A1，observation group A2 via the random number table，with 47 cases. Group B were divided into control group B， observation group B1，observation group B2 via the random number table， with 36 cases. Based on the conventional treatment，control group A and observation group B were treated with compound anisodine injections in compound anisodine 2ml subcutaneous injection beside the affected side arteriae temporalis superficial; observation group A1，observation group B1 were given were treated with compound anisodine subcutaneous injection beside the affected side arteriae temporalis superficialis with vitamin B。intramuscular injection，once a day. Observation group A2，observation group B2 were given mixture of the compound anisodine and vitamin B12 subcutaneous injection beside the affected side arteriae temporalis superficialis，once a day. The period of treatment of the both groups was three courses (two weeks as one course). Visual acuity changes and visual field defect of each group were compared before and after treatment，changes of eyesight and vision were set as the efficacy indicators. RESULTS： After treatment，the recovery of eyesight and vision and total effective rate were significantly higher than those of control group % and observation group A2 % observation group B2 were respectively higher than those of observation group A1 and observation group B1 % with statistical significance ( P < 0. 05 )； There were no sever adverse drug reactions in all patients during treatment. CONCLUSIONS： The efficacy of compound anisodine injections combined with vitamin B12 injections in treatment of primary and secondary ischemic optic neuropathy is remarkable，with high safety. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To compare the effects between vitamin A palmitate and bromfenac sodium on anti-ocular surface damage in treatment of patients with intraocular pressure controlled by long-term application of travoprost. METHODS: 153 patients(208 eyes) with intraocular pressure controlled by long-term application of travoprost admitted into Zhengzhou Second Hospital from May 2015 to Oct. 2017 were selected and divided into control group(51 cases, 71 eyes), observation group 1(51 cases, 68 eyes) and observation group 2(51 cases, 69 eyes) via random number table. The control group was treated with travoprost eye drops, the observation group 1 was treated with vitamin A palmitate eye gel based on the control group, while the observation group 2 was given bromfenac sodium hydrate eye drops based on the control group. Evaluations on break-up time(BUT), Schirmer I test(SIt), corneal fluorescein staining(CFS), morphology and function of meibomian glands were conducted and compared among three groups before and after treatment. RESULTS: At 30 days after treatment, the CFS score, BUT and SIt results of observation group 1 were significantly better than those of control group and observation group 2; the morphology and function of meibomian glands of observation group 2 was significantly better than that of control group and observation group 1, with statistically significant differences(P<0.05). CONCLUSIONS: Both vitamin A palmitate and bromfenac sodium can improve ocular surface damage in patients with intraocular pressure controlled by long-term application of travoprost, of which vitamin A palmitate has better repair effect on lacrimal gland cells and corneal cells, and bromfenac sodium has better effects in improving morphology and function of meibomian glands. [ABSTRACT FROM AUTHOR]

Copyright of Evaluation & Analysis of Drug-Use in Hospitals of China is the property of Evaluation & Analysis of Drug-Use in Hospitals of China Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

OBJECTIVE: To investigate the application of local anti-glaucoma drugs in the Second People's Hospital of Zhengzhou (hereinafter referred to as "our hospital"), and then get preliminary information about the clinical application characteristics, drugs distributions and the development tendency of local anti-glaucoma drugs. METHODS: Through drug management system, the consumption amount, consumption sum of anti-glaucoma drugs were statistically collected. And comprehensively analysis was conducted on the defined daily dose (DDD), defined daily dose system (DDDs), and daily drug cost (DDC). RESULTS: The sales amount, consumption sum of local anti-glaucoma drugs were in upward trend in our hospital, while timolol decreased,and travoprost and brimonidine both had a significant increase. DDDs of timolol and travoprost had changed significantly, and the others had no significant change. CONCLUSIONS: Timolol has been gradually replaced by carteolol in the process of clinical application; brinzolamide plays an important role in glaucoma medications; and the use rate of travoprost stepped up steadily yearly in clinical application. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To probe into the clinical efficacy and safety of Sanjin tablets combined with Norfloxacin tablets in treatment of urinary tract infection. METHODS: 84 cases with urinary tract infection admitted into the hospital from Aug. 2010 to Jun. 2014 were selected as the research objects, who were divided into observation group and control group, with 42 cases in each group. The observation group were treated with Sanjin tablets combined with norfloxacin tablets while the control group only received orally Norfloxacin tablets. The time of symptom relief, the clinical efficacy and adverse reactions of the two groups were compared. RESULTS:The time of frequent micturition, urgency of urination, dysuria, abdominal bulge, fever, hematuria and the time of pain relief in kidney in the observation group were respectively (5.10 ±1.32) d, (5.77 ±2.31) d, (2.66 ±1.34) d, (4.69 ±2.16) d, (3.21 ±1.51) d, (3.67 +1.51) d and (3.02 +1.61) d, which were significantly lower than those in the control group(7.87 ±1.51) d, (9.84 ±2.64) d, (4.21 ±0.58) d, (5.83 ±2.61) d, (4.82 ±1.64) d, (6.86 ±1.64) d and (6.58 ±1.94) d, and the difference between groups was statistically significant (P<0.05). The total efficiency of the observation group was [97.62%(41/42)], significantly higher than[ 85.71%(36/42)]of the control group, with statistically significant difference (P<0.05 ). The rate of adverse reactions in observation group was [ 7.14%(3/42)], and in control group was [ 9.52%(4/42)], there was no significant difference between two groups (χ2 =0.156, P >0.05). CONCLUSIONS: Sanjin tablets combined with Norfloxacin tablets in treatment of urinary tract infection has a significant efficacy, which can shorten the time of symptoms with safe and reliable effect; and it is of high value in clinical application. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To probe into the clinical efficacy of different administration timing of recombinant human brain natriuretic peptide on acute myocardial infarction (AMI) patients after percutaneous coronary intervention (PCI) and its effects on major adverse cardiovascular events ( MACE). METHODS: Totally 386 AMI patients undergoing PCI admitted into the Hengshui People’s Hospital and the No. 4 People’s Hospital of Hengshui from Apr. 2019 to Mar. 2022 were selected to be divided into observation group and control group via random number table method, via 193 cases in each group. The observation group given recombinant human brain natriuretic peptide at emergency PCI, while the control group was given recombinant human brain natriuretic peptide at 24 h after PCI, the usage, dosage and treatment courses of recombinant human brain natriuretic peptide were the same in both groups. The clinical efficacy, cardiac function indicators, renal function indicators, serum cytokines and incidences of adverse drug reactions of both groups were observed; the incidences of MACE of both groups at 3 months after hospital discharge were observed. RESULTS: Totally 371 patients finished the research, including 187 cases in the observation group and 184 cases in the control group. After treatment, the total effective rate of the observation group was 88. 77% (166 / 187), which was higher than that of the control group (80. 98%, 149 / 184), with statistically significant difference (P< 0. 05). After treatment, the left ventricular ejection fraction and left ventricular end-diastolic dimension were larger, and the left ventricular end-systolic dimension was smaller in the observation group than those in the control group at 4 weeks and 12 weeks after operation; the serum N-terminal B-type pronatriuretic peptide, homocysteine and ischemia modified albumin levels of the observation group were significantly lower than those of the control group at 4 weeks and 12 weeks after operation; the urea nitrogen and serum creatinine were lower, and the glomerular filtration rate was higher in the observation group than those in the control group at 48 h and one week after operation, all above differences were statistically significant (P< 0. 05). The incidence of MACE of the observation group was 10. 70% (20 / 187), which was lower than that of the control group (17. 93%, 33 / 184), with statistically significant difference (P<0. 05). CONCLUSIONS: The application of recombinant human brain natriuretic peptide on AMI patients at PCI can significantly improve the clinical efficacy, promote cardiac function and renal function, reduce the incidence of long-term MACE. [ABSTRACT FROM AUTHOR]