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Copyright of Evaluation & Analysis of Drug-Use in Hospitals of China is the property of Evaluation & Analysis of Drug-Use in Hospitals of China Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

OBJECTIVE: To evaluate the clinical practice guidelines for antiplatelet therapy in patients with acute coronary syndrome (ACS) published domestically and internationally from 2010 to 2019 according to appraisal of guidelines for research and evaluation Ⅱ (AGREE Ⅱ) tool. METHODS: Guidelines and related literature for the treatment of antiplatelet drugs in patients with ACS published domestically and internationally from 2010 to 2019 were selected as the research object, and AGREE Ⅱ was used to perform systematic review, and the differences between recommended contents of the guidelines were analyzed. RESULTS: A total of 10 relevant guidelines were included, including 7 treatment guidelines and 3 expert recommendations and consensus. Mean scores for each domain of AGREE Ⅱ were (82. 5±8. 7)% for scope and purpose, (67. 5±15. 3)% for participants, (68. 7±18. 2)% for rigor of formulation, ( 89. 3 ± 4. 0)% for clarity of presentation, ( 68. 1 ± 13. 8)% for applicability, ( 54. 8 ± 12. 3)% for editorial independence, and (65. 7±12. 3)% for overall evaluation. The intra-group correlation coefficient and 95%CI was 0. 89 ( 0. 72-0. 92), indicating a high degree of consistency in researcher scores. All guidelines recommend aspirin + P2Y12 receptor antagonist combined with antiplatelet therapy after surgery. CONCLUSIONS: Clinical guidelines recommend aspirin + P2Y12 receptor antagonist combined with antiplatelet therapy for 12 months. Genetic testing is not necessary in patients with ACS. [ABSTRACT FROM AUTHOR]

Copyright of Evaluation & Analysis of Drug-Use in Hospitals of China is the property of Evaluation & Analysis of Drug-Use in Hospitals of China Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

OBJECTIVE: To probe into the effects of risperidone combined with prednisolone on core symptoms and inflammatory factors in children with degenerative autism spectrum disorder (ASD) . METHODS: Totally 218 children with degenerative ASD admitted into the First Affiliated Hospital of Xi’an Jiaotong University from Nov. 2018 to Apr. 2020 were extracted to be divided into the prednisolone group and the control group via the random number table, with 109 cases in each group. All children were treated with Risperidone tablets for 12 weeks. On the basis of the above treatment, the prednisolone group was treated with Prednisolone tablets at a dose of 1 mg/d for 12 weeks. Differences of childhood Autism Rating Scale (CARS) scores and autism behavior rating scale scores between two groups were compared at baseline, after treatment of 4, 8 and 12 weeks. Levels of inflammatory factors in two groups were observed at baseline and after treatment of 12 weeks. The adverse drug reactions of two groups were recorded. RESULTS: The CARS scores of the prednisolone group were significantly lower than those of the baseline after treatment of 4, 8 and 12 weeks, and the difference was statistically significant (F = 22. 493, P < 0. 001) . The CARS scores of the prednisolone group decreased significantly over time, and the difference was statistically significant (F =22. 493, P < 0. 001) . Emotional instability/self-harm attack score (F = 3. 347, P = 0. 027), social withdrawal/sluggishness score (F = 25. 173, P < 0. 001), stereotyped behavior score (F = 3. 179, P = 0. 032) and hyperactivity scores (F = 5. 347, P = 0. 003) of the prednisolone group were significantly lower than those of the baseline after treatment of 4, 8 and 12 weeks, and the differences were statistically significant. After treatment of 12 weeks, the interferon-γ (t = 2. 487, P = 0. 020), interleukin-1β (t = 5. 824, P < 0. 001), interleukin-6 (t = 2. 763, P = 0. 011), interleukin-8 (t = 2. 547, P = 0. 018) off the prednisolone group were significantly lower than those of the baseline, with statistically significant differences. There was no significant difference in the incidence of adverse drug reactions between the prednisolone group and the control group[2. 8% (3/109) compared with 0 (0/109), χ2= 1. 352, P = 0. 245]. CONCLUSIONS: Risperidone combined with prednisolone in the treatment of degenerative ASD can significantly improve the core clinical symptoms of emotional instability/self-harm attack score, social withdrawal/sluggishness, stereotyped behavior and hyperactivity, and reduce the inflammatory response of patients with higher safety. [ABSTRACT FROM AUTHOR]

OBJECTIVE:To investigate the application status of antibioticsin outpatient and emergency department of Dandong Traditional Chinese Medicine Hospital (hereinafter referred to as“our hospital”), so as to provide reference for the scientific management and rational application of antibiotics. METHODS:402 314 prescriptions of outpatient and emergency department of our hospital during 2013-2015 were extracted. According to thebasis of “Prescription Management Method“and“Guiding Principle of Clinical Application of Antibiotics”, statistical analysis was conducted on the application rate, categories selection, drug combination and defined daily dose system (DDDs) of antibiotics, some suggestions were put forward to improve the existing problems. RESULTS:Of the 402 314 prescriptions, 56 324 cases were antibiotics prescriptions, the application rate was 14.00%;among which the application rate of antibiotics in pediatrics took the lead (25.18%,14 181prescriptions). Antibiotics often used in respiratory system disease, mainly for pneumonia assingle drug. Cephalosporins were used most, which had 7 varieties,including 42 898 times;DDDs of cefoperazone-sulbactam sodium took the lead;intravenous administration was the main route of administration; and irrational prescription was mainly in no indication. CONCLUSIONS: The application of antibioticsino utpatient and emergency department of our hospital is basically rational, yet there are still some irrational phenomenon, it is necessary to strengthen the supervision and train of clinical application of knowledge of antibiotics. [ABSTRACT FROM AUTHOR]