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OBJECTIVE: To realize the application status of off-label drug use in psychiatry department, and to provide reference for the formulation of management for off-label drug use in psychiatry department. METHODS: The rationality and necessity of off-label drug use in psychiatry department of Beijing Huilongguan Hospital (hereinafter referred to as "our hospital") were analyzed, and then countermeasures and suggestions on off-label drug use were put forward. RESULTS: The application of off-label drug use in clinical cases was rational and necessary to some extent,yet the inspection to the clinical use of psychotic drugs should be implemented. CONCLUSIONS: It is necessary to establish effective regulatory measures by supervision department, adopt effective mechanism of communication between medical staff and patients by medical institutions, and strengthen the supervision and guidance of pharmacists, so as to reduce irrational drug use and risk of off-label drug use. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To investigate and analyze the application of antibiotics in Beijing Huilongguan Hoapital (hereinafter referred to as "our hospital"), so as to strengthen the management of application of antibiotics and provide reference for the rational use of antibiotics. METHODS: Retrospective review was adopted to retrieve the medical records of 4114 patients discharged from our hospital in 2013, the application situation of antibiotics was statistically analyzed. RESULTS: Of the total 4114 cases, 446 patients used antibiotics, the infection rate was 10.84%, respiratory system infection was the main part (69.28%). Cephalosporins and 4-quinolones were used with a high frequency, the rate of etiological test was 55.37%and the rate of clinical rational application of antibiotics was 79.39%. CONCLUSIONS:The rationality of clinical application of antibiotics in our hospital is relatively high, but there are still some irrational phenomenon in the clinical application of antibiotics in our hospital. It is necessary to further strengthen the prevention of hospital infections and the supervision of clinical application of antibiotics, and promote the rational application of antibiotics. [ABSTRACT FROM AUTHOR]